Wireless molecular sensor system and process

• US 9,011,333 B2
• Filed: 05/11/2011
• Issued: 04/21/2015
• Est. Priority Date: 05/11/2010
• Status: Active Grant

• Current Assignee: Magna Equities I, LLC
• Original Assignee: Veriteq Acquisition Corporation (VeriTeQ Corp.)
• Inventors: Geissler, Randolph K., Nelson, Scott, Lewis, Steve
• Primary Examiner(s): D'ANGELO, MICHAEL J
• Application Number:
  US13/105,495
• Publication Number:
  US 20110282175A1
• Time in Patent Office: 1,441 Days
• Field of Search: 600/309, 600/316, 600345-347, 600/365, 606/167, 606181-183, 604 64- 66, 702/19, 702 22- 23, 20440301-40315, 422/50, 422420-429, 436/68, 435 4- 5, 435/14
• US Class Current: 600/365
• CPC Class Codes: A61B 5/0031 Implanted circuitry
• CPC Class Codes: A61B 5/14503 invasive, e.g. introduced into the body by a catheter or needle or using implanted sensors A61B5/1459, A61B5/1464, A61B5/1473, A61B5/1482, A61B5/14865 take precedence

Abstract

Wireless molecular sensor methods and systems integrate radio frequency (RF) technology to interrogate, power, operate and/or readout signals corresponding to levels of molecules of interest from microelectromechanical systems (MEMS) implanted within the body. Various alternative embodiments are disclosed.

Claims

1. A system for wireless detection of an analyte in vivo, comprising an implantable sensor and an external reader,

said sensor comprising at least one microelectromechanical system (MEMS) device sensing the analyte, said MEMS device coupled to an integrated circuit for communicating with the reader,

said reader transmitting radio frequency (RF) energy powering the sensor and receiving RF signals from the sensor related to changes in the MEMS device reflecting levels of analyte,

wherein the MEMS device is a microcantilever, and

wherein the system determines analyte levels by measuring changes in amplitude of oscillation of the MEMS device.

2. The system of claim 1, wherein the MEMS device is a dual beam microcantilever.

3. The system of claim 1, wherein the MEMS device is coated on one or more surfaces with at least one coating agent.

4. The system of claim 3, wherein one or more smooth surfaces of the MEMS device are treated to increase surface area for the coating agent.

5. The system of claim 3, wherein the coating agent is a boronic acid-based chemical.

6. The system of claim 3, wherein the coating agent is an artificial receptor.

7. The system of claim 6, wherein the artificial receptor is used in combination with a competitive binding molecule.

8. The system of claim 7, wherein the competitive binding molecule is at least one of a dextran and a dendrimer.

9. The system of claim 1, wherein the sensor further comprises a semi-permeable membrane positioned between the MEMS device and bodily fluids.

10. The system of claim 1, wherein the system determines analyte levels by measuring changes in amplitude of oscillation of the MEMS device.

11. The system of claim 1, wherein the reader transmits and receives RF energy in the KHz range.

12. The system of claim 1, wherein the analyte is glucose.

13. The system of claim 1, wherein said integrated circuit further comprises one or more of:

an antenna, a power harvesting component, a clock component, a signal detection component, an analog to digital converter component, and an RF modulation component.