System and method for dual energy and/or contrast enhanced breast imaging for screening, diagnosis and biopsy

• US 9,020,579 B2
• Filed: 03/08/2012
• Issued: 04/28/2015
• Est. Priority Date: 03/08/2011
• Status: Active Grant

• Current Assignee: Hologic Incorporated
• Original Assignee: Hologic Incorporated
• Inventors: Smith, Andrew P., Stein, Jay A., Jing, Zhenxue, Ren, Baorui, Niklason, Loren, Ruth, Christopher, Shaw, Ian
• Primary Examiner(s): Cwern, Jonathan
• Assistant Examiner(s): Gillman, Amelie R
• Application Number:
  US13/415,675
• Publication Number:
  US 20120238870A1
• Time in Patent Office: 1,146 Days
• Field of Search: 600/425, 600/431
• US Class Current: 600/427
• CPC Class Codes: A61B 10/04 Endoscopic instruments
• CPC Class Codes: A61B 6/025 Tomosynthesis
• CPC Class Codes: A61B 6/12 Arrangements for detecting or locating foreign bodies
• CPC Class Codes: A61B 6/4035 the source being combined with a filter or grating
• CPC Class Codes: A61B 6/4417 related to combined acquisition of different diagnostic modalities
• CPC Class Codes: A61B 6/463 characterised by displaying multiple images or images and diagnostic data on one display
• CPC Class Codes: A61B 6/466 adapted to display 3D data
• CPC Class Codes: A61B 6/481 involving the use of contrast agents
• CPC Class Codes: A61B 6/482 involving multiple energy imaging
• CPC Class Codes: A61B 6/502 for diagnosis of breast, i.e. mammography
• CPC Class Codes: A61B 6/5235 combining images from the same or different ionising radiation imaging techniques, e.g. PET and CT
• CPC Class Codes: F04C 2270/041 Controlled or regulated

Abstract

Systems and methods for x-ray imaging a patient'"'"'s breast in combinations of dual-energy, single-energy, mammography and tomosynthesis modes that facilitate screening for and diagnosis of breast abnormalities, particularly breast abnormalities characterized by abnormal vascularity.

Claims

1. A method of multi-mode x-ray examination of a contrast-enhanced patient'"'"'s breast comprising:

introducing vascular contrast agent into a patient'"'"'s breast;

obtaining (i) a multiplicity of single-energy x-ray 2D tomosynthesis projection images of the patient'"'"'s breast, (ii) then a low-energy x-ray 2D mammogram of the breast, and (iii) a high-energy x-ray 2D mammogram of the breast;

wherein said 2D tomosynthesis projection images and said 2D mammograms are taken in a single breast compression;

computer-processing the 2D tomosynthesis projection images into 3D slice images that represent respective slices of the breast;

computer-processing the 2D low-energy mammogram and the 2D high-energy mammogram to form a weighted combination 2D image highlighting vascularity in the breast; and

displaying the combination 2D image and one or more of the 3D slice images;

wherein the displayed combination 2D image facilitates identification of a position of a possible vascular abnormality in two dimensions, and the one or more 3D slice images facilitate identification of a position of the abnormality in three dimensions as well as visualization of appearance of the abnormality in respective slice images.

2. The method of claim 1 in which said displaying comprises concurrently displaying the combination 2D image and at least one of the 3D slice images.

3. The method of claim 1 in which said displaying comprises displaying the combination 2D image and at least one of the 3D slice images in mutual registration.

4. The method of claim 1 in which said displaying comprises concurrently displaying the combination 2D image and a plurality of the 3D slice images.

5. The method of claim 1 in which said displaying comprises concurrently displaying the combination 2D image and a subset of the 3D slice images, wherein the subset comprises 3D slice images in which the abnormalities appear and the subset is automatically selected in response to an identification of the abnormality in the combination 2D image.

6. A method of multi-mode x-ray examination of a contrast-enhanced patient'"'"'s breast comprising:

introducing vascular contrast agent into a patient'"'"'s breast;

obtaining (i) 3D slice images of the patient'"'"'s breast that represent respective slices of the breast and are reconstructed through computer-processing a multiplicity of single-energy x-ray 2D tomosynthesis projection images of the patient'"'"'s breast, (ii) a low-energy x-ray 2D mammogram of the breast, and (iii) a high-energy x-ray 2D mammogram of the breast;

wherein said 2D tomosynthesis projection images are obtained before and said 2D mammograms, and the 2D tomosynthesis projection images and the mammograms are taken in a single breast compression;

computer-processing the 2D low-energy mammogram and the 2D high-energy mammogram to form a weighted combination 2D image highlighting vascularity in the breast; and

displaying the combination 2D image and one or more of the 3D slice images;

wherein the displayed combination 2D image facilitates identification of a position of a possible vascular abnormality in two dimensions, and the displayed one or more 3D slice images facilitate identification of the position of the abnormality in three dimensions as well as visualization of appearance of the abnormalities in respective slice images.

7. The method of claim 6 in which said displaying comprises concurrently displaying the combination 2D image and at least one of the 3D slice images.

8. The method of claim 6 in which said displaying comprises displaying the combination 2D image and at least one of the 3D slice images in mutual registration.

9. The method of claim 6 in which said displaying comprises concurrently displaying the combination 2D image and a plurality of the 3D slice images.

10. A method of multi-mode x-ray examination of a patient'"'"'s breast comprising:

obtaining, from a single compression of the breast;

(a) 3D slice images representing respective slices of a patient'"'"'s breast formed by computer-processing, through a reconstruction algorithm, a multiplicity of x-ray 2D tomosynthesis projection images of the breast taken at respective angles clan imaging x-ray beam to the breast; and

(b) a 2D combination image of a low-energy 2D x-ray mammogram of the breast and a high-energy 2D x-ray mammogram of the breast in the presence of a contrast agent therein, wherein the 2D mammograms are obtained after the 2D tomosynthesis projection images; and

concurrently displaying on a computer display the 2D combination image and one or more of the 3D slice images;

wherein the displayed combination 2D image facilitates identification of a position of a possible vascular abnormality in two dimensions, and the displayed one or more 3D slice images facilitate identification of the position of the abnormality in three dimensions as well as visualization of appearance of the abnormalities in respective slice images.

11. The method of claim 10 in which said 2D tomosynthesis projection images are single-energy images.

12. The method of claim 10 in which said combination 2D image is a weighted combination of the high-energy and low-energy images.

13. The method of claim 10 in which said 2D tomosynthesis projection images are dual-energy images.

14. A system for imaging a patient'"'"'s breast comprising:

a data acquisition and computer-processing system configured to image a patient'"'"'s breast with x-rays and generate, from a single compression of the breast, (i) 3D slice images of the patient'"'"'s breast that represent respective slices of the breast and are reconstructed through computer-processing a multiplicity of single-energy x-ray 2D tomosynthesis projection images of the patient'"'"'s breast, (ii) a low-energy x-ray 2D mammogram of the breast, and (iii) a high-energy x-ray 2D mammogram of the breast, wherein the 2D mammograms are obtained after the 2D tomosynthesis projection images;

said data acquisition and computer-processing system being further configured to combine said 2D low-energy mammogram and 2D high-energy mammogram to form a combination 2D image highlighting vascularity in the breast; and

a computer display system configured to selectively display the combination 2D image and one or more of the 3D slice images;

wherein the displayed combination 2D image facilitates identification of a position of a possible vascular abnormality in two dimensions, and the displayed one or more 3D slice images facilitate identification of the position of the abnormality in three dimensions as well as visualization of appearance of the abnormalities in respective slice images.

15. The system of claim 14 in which the data acquisition and computer-processing system includes a computerized workstation configured to respond to an identification of an abnormality in said combination 2D image by automatically selecting a subset of said 3D slice images, which subset comprises the 3D slice images in which the identified abnormality appears, and said computer display system is further configured to concurrently display the combination 2D image and said subset of 3D slice images.

16. The system of claim 14 in which the data acquisition and computer-processing system is configured to computer-process at least one of (i) the 3D slice images and (ii) the 2D tomosynthesis projection images to synthesize at least one of (a) the low-energy mammogram and (b) the high-energy mammogram.

17. The system of claim 14 including a computer-aided detection (CAD) processor coupled with the data acquisition and computer-processing system, wherein the CAD processor is configured to apply a computer aided detection algorithm to at least some of (i) the one or more 3D slices images, (ii) the 2D tomosynthesis projection images, and (iii) the mammograms to identify suspected abnormalities, and the CAD processor is coupled with the computer display system and configured to supply for display identifications of suspected abnormalities.

18. The system of claim 14 in which system for imaging a patient'"'"'s breast further includes (i) a variable collimator configured to control the area of said x-ray beam at an imaging plane of an imaging receptor of the x-rays, and (ii) a collimator controller coupled with the data acquisition and computer-processing system to receive commands therefrom regarding control over the area of the x-ray beam.

19. The system of claim 14 in which the computer display system is configured to selectively display concurrently the combination 2D image and one or more of the 3D slice images.

20. The system of claim 14 in which the data acquisition and computer-processing system is configured to image the patient'"'"'s breast with x-rays in the presence of a contrast agent in the breast.