Use of substituted heterocyclic compounds to control sea lice on fish

• US 9,023,836 B2
• Filed: 06/15/2011
• Issued: 05/05/2015
• Est. Priority Date: 06/18/2010
• Status: Expired due to Fees

• Current Assignee: Novartis Tiergesundheit GmbH (Elanco Animal Health, Inc.)
• Original Assignee: Novartis Tiergesundheit GmbH (Elanco Animal Health, Inc.)
• Inventors: Perret, Jean-Luc, Blaser, David, Nanchen, Steve
• Primary Examiner(s): SAEED, KAMAL A
• Application Number:
  US13/805,206
• Publication Number:
  US 20130095126A1
• Time in Patent Office: 1,420 Days
• Field of Search: None
• US Class Current: 514/143
• CPC Class Codes: A01N 43/80 five-membered rings with one nitrogen atom and either one oxygen atom or one sulfur atom in positions 1,2
• CPC Class Codes: A61K 31/42 Oxazoles
• CPC Class Codes: A61K 31/422 not condensed and containing further heterocyclic rings
• CPC Class Codes: A61K 31/4439 containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole nicotine A61K31/465
• CPC Class Codes: A61K 31/506 not condensed and containing further heterocyclic rings
• CPC Class Codes: A61K 39/00 Medicinal preparations containing antigens or antibodies materials for immunoassay G01N33/53
• CPC Class Codes: A61K 45/06 Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca

Abstract

The present invention relates to the use of compounds of formula

wherein the variables are as defined in the description, in the free form or in salt form, for controlling sea lice on fish.

Claims

1. A method of controlling sea lice in and on fish, which comprises treating the sea lice by an in-feed treatment, wherein an active substance is added to the feed provided to the fish, said active substance being a compound of formula

2. A method according to claim 1, wherein R′

and R″

40 are each independently of the other chlorine and R″

is H.

3. A method according to claim 1, wherein the active substance is of formula (Ia′

).

4. A method according to claim 1, wherein the active substance is of formula (Ia″

′

).

5. A method according to claim 1, wherein the fish are of the Salmonidae family.

6. A method according to claim 1, wherein the sea lice are of the Copepodae class.

7. A method according to claim 3, wherein the active substance is of formula

8. A method according to claim 4, wherein the active substance is of formula

9. A method according to claim 5, wherein the fish are selected from the group consisting of Salmo salar, Salmo trutta, Oncorhynchus mykiss, Oncorhynchus gorbuscha, Oncorhynchus keta, Oncorhynchus nekra, Oncorhynchus kisutch, Oncorhynchus tshawytscha, Oncorhynchus mamson, Salvelinus species and Salmo clarkii.

10. A method according to claim 6, wherein the sea lice are selected from the group consisting of Lepeophtheirus salmonis, Caligus elongatus and C. rogercresseyii.