Fluid delivery with in vivo electrochemical analyte sensing
First Claim
Patent Images
1. An apparatus comprising:
- a subcutaneously insertable element that comprises a proximal portion and a distal portion, the distal portion being configured for subcutaneous placement within the body of a patient, the subcutaneously insertable element comprising a cannula having an internal volume and a wall surface;
a sensor that interacts with one or more analytes and generates a signal that is representative of a concentration of the one or more analytes, the sensor comprising a first electrode and a second electrode electrically isolated from the first electrode, the first electrode and second electrode being secured to the cannula;
a pump for delivering a therapeutic fluid through the distal portion of the subcutaneously insertable element via a flow path from a reservoir configured to contain the therapeutic fluid to the subcutaneously insertable element;
a processor for receiving the signal from the sensor and for determining the concentration of the one or more analytes within the body of the patient based on the signal, the processor receiving the signal via at least one continuous electrical signal path between the distal end of the subcutaneously insertable element and the processor; and
an external device comprising a single housing or at least two physically connected housings containing the pump, the processor, the reservoir, and the at least one continuous electrical signal path between the proximal end of the subcutaneously insertable element and the processor, the proximal portion of the subcutaneously insertable element being in direct physical contact with the single housing or one of the at least two physically connected housings,wherein the sensor is disposed within the distal portion of the subcutaneously insertable element, with the first electrode and the second electrode being disposed on an inner surface of the cannula, and with at least part of the wall surface of the cannula being permeable or semi-permeable.
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Abstract
One or more therapeutic fluids, such as for example insulin can be delivered to a body. In addition or alternatively, the concentrations of one or more analytes can be measured in vivo. A feedback process can be used to regulate levels of the one or more analytes based on the measurements via delivery of the one or more therapeutic fluids. Related systems, apparatus, methods, and/or articles are also described.
42 Citations
25 Claims
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1. An apparatus comprising:
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a subcutaneously insertable element that comprises a proximal portion and a distal portion, the distal portion being configured for subcutaneous placement within the body of a patient, the subcutaneously insertable element comprising a cannula having an internal volume and a wall surface; a sensor that interacts with one or more analytes and generates a signal that is representative of a concentration of the one or more analytes, the sensor comprising a first electrode and a second electrode electrically isolated from the first electrode, the first electrode and second electrode being secured to the cannula; a pump for delivering a therapeutic fluid through the distal portion of the subcutaneously insertable element via a flow path from a reservoir configured to contain the therapeutic fluid to the subcutaneously insertable element; a processor for receiving the signal from the sensor and for determining the concentration of the one or more analytes within the body of the patient based on the signal, the processor receiving the signal via at least one continuous electrical signal path between the distal end of the subcutaneously insertable element and the processor; and an external device comprising a single housing or at least two physically connected housings containing the pump, the processor, the reservoir, and the at least one continuous electrical signal path between the proximal end of the subcutaneously insertable element and the processor, the proximal portion of the subcutaneously insertable element being in direct physical contact with the single housing or one of the at least two physically connected housings, wherein the sensor is disposed within the distal portion of the subcutaneously insertable element, with the first electrode and the second electrode being disposed on an inner surface of the cannula, and with at least part of the wall surface of the cannula being permeable or semi-permeable. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19)
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20. A method comprising:
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detecting, with a sensor secured to a distal end of a subcutaneously insertable element, a concentration of one or more analytes within a body of a patient, the subcutaneously insertable element comprising a proximal end opposite to the distal end, the proximal end being in direct physical contact with a single housing or one of at least two physically connected housings of an external device, the single housing or the at least two physically connected housings containing a reservoir containing a therapeutic fluid, a pump, a processor, and at least one continuous electrical signal path between the proximal end of the subcutaneously insertable element and the processor; and dispensing a therapeutic fluid to the body of the patient through a cannula of the subcutaneously insertable element, the dispensing occurring by action of the pump and via a flow path between the reservoir and the cannula; wherein the sensor comprises a first electrode and second electrode each being disposed on an inner surface of the subcutaneously insertable element, and wherein at least part of a wall surface of the cannula is permeable or semi-permeable. - View Dependent Claims (21, 22, 23)
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24. An apparatus for delivering insulin to a body of a patient and for sensing glucose, the apparatus comprising:
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a cannula that comprises a proximal portion and a distal portion, the distal portion configured for subcutaneous placement within the body of the patient, the cannula further comprises a wall surface and an internal volume; a sensor that electrochemically interacts with glucose and generates a signal that is representative of a glucose concentration, the sensor disposed within the distal portion of the cannula; and a patch unit securable to a body of a patient, the patch unit including; a reusable part housing containing at least a portion of a pump for delivering insulin from a reservoir into the body of the patient through the cannula, a processor that receives and processes the signal from the sensor to determine the glucose concentration within the body of the patient, and at least one first electrical conducting element forming a first continuous electrical path between the processor and at least one first electrical contact in the reusable part housing, the processor being configured to control the pump to deliver the insulin based on the glucose concentration determined by the processor; and a disposable part housing in direct physical contact with the proximal portion of the cannula and containing at least one second electrical conducting element forming a second continuous electrical path between the sensor and at least one second electrical contact in the disposable part housing, the at least one second electrical contact being configured to connect to the at least one first electrical contact to form a completed electrical path between the sensor and the processor when the disposable part housing and the reusable part housing are connected to enable operation of the patch unit; wherein the sensor comprises a first electrode and a second electrode electrically isolated from the first electrode, the first electrode and second electrode being secured to the cannula, and with at least part of the wall surface of the cannula being permeable or semi-permeable. - View Dependent Claims (25)
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Specification