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Fluid delivery with in vivo electrochemical analyte sensing

  • US 9,028,409 B2
  • Filed: 12/21/2007
  • Issued: 05/12/2015
  • Est. Priority Date: 12/22/2006
  • Status: Expired due to Fees
First Claim
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1. An apparatus comprising:

  • a subcutaneously insertable element that comprises a proximal portion and a distal portion, the distal portion being configured for subcutaneous placement within the body of a patient, the subcutaneously insertable element comprising a cannula having an internal volume and a wall surface;

    a sensor that interacts with one or more analytes and generates a signal that is representative of a concentration of the one or more analytes, the sensor comprising a first electrode and a second electrode electrically isolated from the first electrode, the first electrode and second electrode being secured to the cannula;

    a pump for delivering a therapeutic fluid through the distal portion of the subcutaneously insertable element via a flow path from a reservoir configured to contain the therapeutic fluid to the subcutaneously insertable element;

    a processor for receiving the signal from the sensor and for determining the concentration of the one or more analytes within the body of the patient based on the signal, the processor receiving the signal via at least one continuous electrical signal path between the distal end of the subcutaneously insertable element and the processor; and

    an external device comprising a single housing or at least two physically connected housings containing the pump, the processor, the reservoir, and the at least one continuous electrical signal path between the proximal end of the subcutaneously insertable element and the processor, the proximal portion of the subcutaneously insertable element being in direct physical contact with the single housing or one of the at least two physically connected housings,wherein the sensor is disposed within the distal portion of the subcutaneously insertable element, with the first electrode and the second electrode being disposed on an inner surface of the cannula, and with at least part of the wall surface of the cannula being permeable or semi-permeable.

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