Implantable device for acquisition and monitoring of brain bioelectric signals and for intracranial stimulation

• US 9,031,657 B2
• Filed: 04/17/2012
• Issued: 05/12/2015
• Est. Priority Date: 04/21/2011
• Status: Active Grant

• Current Assignee: ab medica SpA
• Original Assignee: ab medica SpA
• Inventors: Cristiani, Paolo, Paris, Antonino, Marchetti, Stefano, Romanelli, Panlaleo, Sebastiano, Fabio
• Primary Examiner(s): MANUEL, GEORGE C
• Application Number:
  US14/111,172
• Publication Number:
  US 20140194944A1
• Time in Patent Office: 1,120 Days
• US Class Current: 607/45
• CPC Class Codes: A61B 5/0031 Implanted circuitry
• CPC Class Codes: A61B 5/369 Electroencephalography [EEG] devices for psychotechnics A61B5/16
• CPC Class Codes: A61B 5/37 Intracranial electroencephalography [IC-EEG], e.g. electrocorticography [ECoG]
• CPC Class Codes: A61B 5/6868 Brain
• CPC Class Codes: A61N 1/0476 Array electrodes (including any electrode arrangement with more than one electrode for at least one of the polarities)
• CPC Class Codes: A61N 1/0529 Electrodes for brain stimulation
• CPC Class Codes: A61N 1/0531 Brain cortex electrodes
• CPC Class Codes: A61N 1/36064 Epilepsy

Abstract

An implantable device for the acquisition and monitoring of brain bioelectric signals is described. The implantable device has a plurality of active electrodes configured to detect brain bioelectric signals, the active electrodes being arranged on a grid connected to an electronic module of the implantable device according to a predefined pattern. The active electrodes are connected to a microprocessor of the electronic module through respective paths formed on the grid and connected to at least one analog input unit arranged in the electronic module, the at least one analog input unit being in turn connected to at least one passive electrode and to the microprocessor through a data bus. The at least one analog input unit has an analog-to-digital converter for each active electrode connected thereto. A data acquisition and processing system, which includes the implantable device is also described.

Claims

1. An implantable device for acquisition and monitoring of brain bioelectric signals, said implantable device comprising:

a) a plurality of active electrodes suitable to be placed in contact with a patient'"'"'s brain and configured to detect brain bioelectric signals, said plurality of active electrodes being arranged on a grid connected to an electronic module of the implantable device, wherein

the active electrodes are connected to a microprocessor of said electronic module through respective paths different from each other, are formed on said grid and are connected to analog input units arranged in the electronic module, wherein

each analog input unit is in turn connected to a respective passive reference electrode and to said microprocessor through a data bus,

each analog input unit is coupled to a respective set of said plurality of active electrodes and comprises an analog-to-digital converter for each active electrode of said plurality of active electrodes connected thereto, said analog-to-digital converter being configured to generate digital replicas of analog signals received from the active electrodes, said microprocessor being configured to simultaneously read outputs of the analog-to-digital converters, and

b) at least one digital-to-analog converter arranged within the microprocessor and configured to generate electrical pulses having predetermined waveform and voltage on one or more pairs of electrodes comprising active electrodes and/or passive electrodes, the microprocessor being configured to perform brain stimulation by activating only the electrodes located in a region of the brain wherein a focus of a brain disease has been identified by simultaneously reading the outputs of the analog-to-digital converters.

2. The implantable device according to claim 1, wherein the grid is made of a flexible printed circuit and wherein the electronic module comprises a rigid printed circuit board, said flexible printed circuit being fixed and electrically connected to said rigid printed circuit board.

3. The implantable device according to claim 1, wherein a flexible printed circuit is made of polyimide and is provided with a coating of biocompatible and non-stick material, said biocompatible and non-slick material being a polymer of the family of poly(para-xylylene).

4. The implantable device according to claim 1, wherein the active electrodes are provided with a rough contact surface.

5. The implantable device according to claim 1, further comprising a transceiver and an antenna that are associated with the electronic module and suitable to allow wireless transmission of data related to the bioelectric signals acquired by the active electrodes, said antenna being connected to said transceiver which is in turn is connected to the microprocessor.

6. The implantable device according to claim 1, further comprising:

a rechargeable battery suitable for supplying the electronic module, and

a winding suitable for converting picked up electromagnetic waves into an electric voltage, said winding being configured to allow charging of said rechargeable battery.

7. The implantable device according to claim 6, further comprising a locating system suited to allow detection of the winding in an operative condition of the implantable device, said locating system comprising an LED associated to the winding.

8. The implantable device according to claim 7, wherein said LED is arranged at a center of the winding and is an infrared-type LED.

9. The implantable device according to claim 1, further comprising:

an amplifier connected to the microprocessor and arranged in the electronic module, said amplifier being configured to amplify the electrical pulses generated by said at least one digital-to-analog converter, and

at least one switch connected to the active electrodes and/or passive electrodes.

10. The implantable device according to claim 9, further comprising a data bus suitable to connect the microprocessor to the at least one switch for selection of the active electrodes and/or passive electrodes to which the electrical pulses, generated by the at least one digital-to-analog converter, are to be sent.

11. A data acquisition and processing system comprising:

a radio base station, said radio base station being provided with an antenna suitable for wireless reception of data relating to brain bioelectric signals transmitted from an antenna of an implantable device for acquisition and monitoring of bioelectric signals, and a portable device, said portable device being provided with an antenna suitable for wireless reception and storage of data transmitted by the antenna of said implantable device, wherein the implantable device is the implantable device according to claim 1.

12. The data acquisition and processing system according to claim 11, wherein the radio base station further comprises a winding configured to generate electromagnetic waves suitable to allow recharging of the rechargeable battery of the implantable device.