Abuse-deterrent pharmaceutical compositions for controlled release

  • US 9,044,402 B2
  • Filed: 04/10/2014
  • Issued: 06/02/2015
  • Est. Priority Date: 07/06/2012
  • Status: Active Grant
First Claim
Patent Images

1. An abuse-deterrent tablet formulated for oral administration of an opioid, the tablet consisting of a tablet composition and, optionally, a cosmetic coat, wherein:

  • the tablet composition comprises;

    about 1-30% w/w of the opioid; and

    about 70-98% w/w of a polyethylene oxide (PEO) having an average molecular weight of from about 400,000 daltons to about 600,000 daltons; and

    the cosmetic coat, when present, covers at least a portion of the tablet composition, and dissolves within 30 minutes after contact with an aqueous media,wherein the tablet composition does not provide immediate release of the opioid even after the abuse-deterrent tablet is subjected to physical tampering selected from crushing, grinding, grating, cutting, or crisping, andwherein the tablet composition exhibits a viscosity of at least 170 mPa·

    s when measured by Viscosity Test #2, or a viscosity of at least 46 Pa·

    s when measured by Viscosity Test #1.

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