Methods of regulating glucose metabolism, and reagents related thereto

  • US 9,044,424 B2
  • Filed: 07/25/2013
  • Issued: 06/02/2015
  • Est. Priority Date: 02/02/1998
  • Status: Expired due to Term
First Claim
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1. A method for modifying glucose metabolism, comprising administering orally to an animal in need thereof a therapeutically effective amount of an inhibitor of dipeptidylpeptidase IV (DPIV) or a pharmaceutically acceptable salt thereof once daily, wherein the inhibitor has a Ki for inhibition of DPIV of 10 nM or less;

  • the duration of the therapeutic effect is at least about 24 hours; and

    the inhibitor is administered in an amount sufficient to increase the plasma half-life of glucagon-like peptide 1 (GLP-1) but not sufficient to suppress the immune system of the animal.

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