Use of icariin and epimedium flavonoids containing icariin to treat diseases associated with myelin sheath lesion

• US 9,050,353 B2
• Filed: 06/07/2011
• Issued: 06/09/2015
• Est. Priority Date: 06/11/2010
• Status: Active Grant

• Current Assignee: Xuanwu Hospital Capital Medical University
• Original Assignee: Xuanwu Hospital Capital Medical University
• Inventors: Li, Lin, Yin, Linlin, Lin, Lili, Zhang, Lan, Wang, Wen, Zhang, Ruyi
• Primary Examiner(s): Jiang, Shaojia Anna
• Assistant Examiner(s): Miller, Dale R
• Application Number:
  US13/703,168
• Publication Number:
  US 20130157966A1
• Time in Patent Office: 1,463 Days
• Field of Search: None
• US Class Current: 1/1
• CPC Class Codes: A61K 31/7048 having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin , digitoxin or digoxin
• CPC Class Codes: A61K 36/296 Epimedium
• CPC Class Codes: A61P 19/04 for non-specific disorders of the connective tissue
• CPC Class Codes: A61P 25/00 Drugs for disorders of the nervous system
• CPC Class Codes: A61P 37/02 Immunomodulators

Abstract

New use of icariin and Epimedium flavaoids containing icariin is provided by the present invention. Specifically, uses of compounds of Formula I or Epimedium containing compounds of formula I, Epimedium flavanoids, or extracts of Epimedium in manufacturing medicaments for treating, preventing, reducing and/or relieving diseases and/or conditoins related to neural myelin sheath impairments, or use of above materials in manufacturing medicaments for relieving demyelination and/or promoting repair of myelin sheath are provided by the present application, wherein, R₁ is selected from H, halogen, —C_1-6 alkyl, and —C(O)—C_1-4 alkyl

Claims

1. A method for alleviating or repairing a disease and/or disorder associated with a nervous system myelin sheath lesion, comprising administering icariin to a patient in need thereof:

further comprising any one of the following items a) to b);

a) the disease and/or disorder associated with nervous system myelin sheath lesion is selected from;

optical neuromyelitis, acute disseminated encephalomyelitis, diffuse sclerosis, concentric circle sclerosis, central pontine myelinolysis, acute inflammatory demyelinating polyneuropathy, and chronic inflammatory demyelinating polyneuropathy;

or

b) the disease and/or disorder associated with nervous system myelin sheath lesion is selected from;

subacute combined degeneration caused by nutrition deficiency diseases, subacute sclerosing panencephalitis caused by viral infection or progressive multifocal leukoencephalopathy, and diabetic neuropathy;

wherein icariin is administered in amounts from 0.1 μ

g to 250 mg per kilogram bodyweight per day.

2. The method of claim 1, wherein the icariin is administered orally.

3. The method of claim 1, wherein the icariin is administered intravenously.

4. The method of claim 1, wherein the icariin is administered intranasally.

5. The method of claim 1, wherein the icariin is administered intraperitoneally.

6. The method of claim 1, wherein the icariin is administered subcutaneously.

7. The method of claim 1, wherein the icariin is administered intramuscularly.

8. The method of claim 1, wherein the icariin is administered topically.

9. The method of claim 1, wherein the icariin is administered as a suppository.

10. A method for alleviating or repairing a disease and/or disorder associated with a nervous system myelin sheath lesion, comprising administering icariin to a patient in need thereof:

further comprising any one of the following items a) to b);

a) the disease and/or disorder associated with nervous system myelin sheath lesion is selected from;

optical neuromyelitis, acute disseminated encephalomyelitis, diffuse sclerosis, concentric circle sclerosis, central pontine myelinolysis, acute inflammatory demyelinating polyneuropathy, and chronic inflammatory demyelinating polyneuropathy;

or

b) the disease and/or disorder associated with nervous system myelin sheath lesion is selected from;

subacute combined degeneration caused by nutrition deficiency diseases, subacute sclerosing panencephalitis caused by viral infection or progressive multifocal leukoencephalopathy, and diabetic neuropathy,

wherein the icariin is administered in a pharmaceutical composition comprising from 0.01 μ

g to 2000 mg icariin per 100 g pharmaceutical composition and a pharmaceutically acceptable carrier.

11. A method for alleviating or repairing a disease and/or disorder associated with a nervous system myelin sheath lesion, comprising administering an epimedium flavonoid comprising from 50 to 90 wt. % icariin to a patient in need thereof:

further comprising any one of the following items a) to b);

a) the disease and/or disorder associated with nervous system myelin sheath lesion is selected from;

optical neuromyelitis, acute disseminated encephalomyelitis, diffuse sclerosis, concentric circle sclerosis, central pontine myelinolysis, acute inflammatory demyelinating polyneuropathy, and chronic inflammatory demyelinating polyneuropathy;

or

b) the disease and/or disorder associated with nervous system myelin sheath lesion is selected from;

subacute combined degeneration caused by nutrition deficiency diseases, subacute sclerosing panencephalitis caused by viral infection or progressive multifocal leukoencephalopathy, and diabetic neuropathy;

wherein icariin is administered in amounts from 0.1 μ

g to 250 mg per kilogram bodyweight per day.