Markers associated with arteriovascular events and methods of use thereof

• US 9,057,736 B2
• Filed: 04/06/2010
• Issued: 06/16/2015
• Est. Priority Date: 06/07/2006
• Status: Active Grant

• Current Assignee: True Health Diagnostics LLC (True Health Group LLC)
• Original Assignee: Health Diagnostic Laboratory Incorporated (True Health Group LLC)
• Inventors: Urdea, Mickey S., McKenna, Michael P., Arensdorf, Patrick A.
• Primary Examiner(s): Cheu, Jacob
• Application Number:
  US12/755,146
• Publication Number:
  US 20110008805A1
• Time in Patent Office: 1,897 Days
• Field of Search: None
• US Class Current: 1/1
• CPC Class Codes: G01N 2800/32 Cardiovascular disorders
• CPC Class Codes: G01N 2800/324 Coronary artery diseases, e.g. angina pectoris, myocardial infarction
• CPC Class Codes: G01N 2800/325 Heart failure or cardiac arrest, e.g. cardiomyopathy, congestive heart failure
• CPC Class Codes: G01N 2800/50 Determining the risk of developing a disease
• CPC Class Codes: G01N 2800/52 Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
• CPC Class Codes: G01N 33/6845 Methods of identifying protein-protein interactions in protein mixtures
• CPC Class Codes: G01N 33/6893 related to diseases not provided for elsewhere
• CPC Class Codes: G01N 33/74 involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
• CPC Class Codes: G16H 50/30 for calculating health indices; for individual health risk assessment
• CPC Class Codes: Y02A 90/10 Information and communication technologies [ICT] supporting adaptation to climate change, e.g. for weather forecasting or climate simulation

Abstract

Disclosed are methods of identifying subjects with arteriovascular disease, subjects at risk for developing arteriovascular disease, methods of differentially diagnosing diseases associated with arteriovascular disease from other diseases or within sub-classifications of arteriovascular disease, methods of evaluating the risk of arteriovascular events in patients with arteriovascular disease, methods of evaluating the effectiveness of treatments in subjects with arteriovascular disease, and methods of selecting therapies for treating arteriovascular disease.

Claims

1. A method for evaluating the risk of a cardiovascular event for a subject comprising:

measuring a panel of at least biomarker CRP, ICAM-1, and age, and

using a value calculated from a linear combination of the measurements of the panel to evaluate the risk of a cardiovascular event.

2. The method of claim 1, wherein the risk evaluation comprises calculating an index value.

3. The method of claim 2, wherein the index value is correlated with the risk of a cardiovascular event.

4. The method of claim 1, wherein the risk evaluation comprises normalizing the biomarker measurements to reference values.

5. The method of claim 1, wherein the measurement of at least one of the biomarkers of the panel is unaffected by treatment of the subject with one or more therapeutic interventions.

6. The method of claim 1, wherein the measurement of at least one of the biomarkers of the panel is affected by treatment of the subject with one or more therapeutic interventions.

7. The method of claim 1, further comprising measuring one or more clinical parameters chosen from body mass index (BMI), diabetes, diastolic blood pressure (DBP), family history (FamHX), hip (circumference), height (HT), ethnicity (RACE), systolic blood pressure (SBP), gender (SEX), smoking, waist (circumference), and weight (WT).

8. The method of claim 1, further comprising one or more additional biomarker chosen from POMC, HDLC, and VEGF.