Multi-mode communication ingestible event markers and systems, and methods of using the same

• US 9,060,708 B2
• Filed: 07/25/2014
• Issued: 06/23/2015
• Est. Priority Date: 03/05/2008
• Status: Active Grant

• Current Assignee: Otsuka Pharmaceutical Company Limited (Otsuka Holdings Company Limited)
• Original Assignee: Proteus Digital Health, Inc. (Otsuka Holdings Company Limited)
• Inventors: Robertson, Timothy, Zdeblick, Mark
• Primary Examiner(s): HUNNINGS, TRAVIS R
• Application Number:
  US14/341,621
• Publication Number:
  US 20150048929A1
• Time in Patent Office: 333 Days
• Field of Search: None
• US Class Current: 1/1
• CPC Class Codes: A61B 2562/08 Sensors provided with means for identification, e.g. barcodes or memory chips
• CPC Class Codes: A61B 2562/162 Capsule shaped sensor housings, e.g. for swallowing or implantation
• CPC Class Codes: A61B 5/0031 Implanted circuitry
• CPC Class Codes: A61B 5/073 Intestinal transmitters
• CPC Class Codes: A61B 5/4833 Assessment of subject's compliance to treatment
• CPC Class Codes: A61B 5/4839 combined with drug delivery
• CPC Class Codes: A61B 5/4848 Monitoring or testing the effects of treatment, e.g. of medication
• CPC Class Codes: A61B 5/6861 Capsules, e.g. for swallowing or implanting
• CPC Class Codes: G06K 7/10297 arrangements for handling protocols designed for non-contact record carriers such as RFIDs NFCs, e.g. ISO/IEC 14443 and 18092 cryptographic protocols H04L9/00; network security protocols H04L63/00; real-time communication protocols in data switching networks H04L65/00; network protocols for data switching network services H04L67/00
• CPC Class Codes: H04B 5/77 for interrogation

Abstract

Aspects of the invention include multi-mode communication ingestible event marker devices. Ingestible event marker devices of the invention include an ingestible component comprising a conductive communication module and at least one additional non-conductive communication module. The non-conductive communication module may be integrated with the ingestible component or at least a portion or all of the non-conductive communication module may be associated with a packaging component of the ingestible event marker device. Additional aspects of the invention include systems that include the devices and one or more receivers, as well as methods of using the same.

Claims

1. A device, comprising:

an ingestible component comprising a first communication module, wherein the first communication module is a conductive communication module configured to modulate a first signal, wherein the first signal is a conductive signal communicated through an electrically conductive medium; and

at least a portion of a second communication module configured to modulate a second signal.

2. The device of claim 1, wherein the second communication module is a non-conductive communication module.

3. The device of claim 1, wherein the ingestible component comprises a partial power source comprising a pair of electrodes fabricated from dissimilar materials.

4. The device of claim 1, comprising a second power source electrically coupled to the second communication module.

5. The device of claim 1, wherein the ingestible component comprises the second communication module.

6. The device of claim 1, wherein at least a portion of the second communication module is configured to be separable from the ingestible component in a manner that does not compromise the function of the conductive communication module.

7. The device of claim 1, wherein the ingestible component comprises an active pharmaceutical agent.

8. The device of claim 1, wherein the ingestible component comprises a physiologically acceptable vehicle.

9. A system comprising:

an ingestible component comprising a first communication module, wherein the first communication module is a conductive communication module configured to modulate a first signal, wherein the first signal is a conductive signal communicated through an electrically conductive medium;

at least a portion of a second communication module configured to modulate a second signal; and

a receiver, wherein the receiver, the first communication module, and the second communication module are configured to transmit information between the receiver and at least one of the first or second communication module.

10. The system of claim 9, wherein the receiver comprises a radio-frequency reader.

11. The system of claim 9, wherein the receiver is configured transmit information to the second communication module.

12. The system of claim 9, wherein the receiver is configured to be removably attached to a living being.

13. The system of claim 9, wherein the receiver is an implantable receiver.

14. The system of claim 9, wherein the receiver is configured as an electrical stimulation device.

15. The system of claim 9, wherein the second communication module is a non-conductive communication module.

16. A device, comprising:

an ingestible component comprising a conductive communication module configured to modulate a conductive signal through an electrically conductive medium; and

at least a portion of another module configured to absorb a second signal.

17. The device of claim 16, wherein the other communication module is a non-conductive communication module.

18. The device of claim 16, wherein the ingestible component comprises a partial power source comprising a pair of electrodes fabricated from dissimilar materials.

19. The device of claim 16, comprising a second power source electrically coupled to the second communication module.

20. The device of claim 16, wherein the ingestible component comprises the other communication module.

21. The device of claim 16, wherein at least a portion of the other communication module is configured to be separable from the ingestible component in a manner that does not compromise the function of the conductive communication module.

22. The device of claim 16, wherein the ingestible component comprises an active pharmaceutical agent.

23. The device of claim 16, wherein the ingestible component comprises a physiologically acceptable vehicle.

24. A system comprising:

an ingestible component comprising a conductive communication module configured to modulate a conductive signal through an electrically conductive medium;

at least a portion of another communication module configured to absorb a signal; and

a receiver configured to communicate information between at least one of the conductive communication or the other communication module.

25. The system of claim 24, wherein the receiver comprises a radio-frequency reader.

26. The system of claim 24, wherein the receiver is configured transmit information to the other communication module.

27. The system of claim 24, wherein the receiver is configured to be removably attached to a living being.

28. The system of claim 24, wherein the receiver is an implantable receiver.

29. The system of claim 24, wherein the receiver is configured as an electrical stimulation device.

30. The system of claim 24, wherein the other communication module is a non-conductive communication module.