Method and apparatus for providing data processing and control in a medical communication system

• US 9,060,719 B2
• Filed: 12/13/2013
• Issued: 06/23/2015
• Est. Priority Date: 05/14/2007
• Status: Active Grant

• Current Assignee: Abbott Diabetes Care Incorporated (Abbott Laboratories Incorporated)
• Original Assignee: Abbott Diabetes Care Incorporated (Abbott Laboratories Incorporated)
• Inventors: Hayter, Gary Alan, McGarraugh, Geoffrey V., Doniger, Kenneth J.
• Primary Examiner(s): SUGLO, JANET L
• Application Number:
  US14/106,000
• Publication Number:
  US 20140100796A1
• Time in Patent Office: 557 Days
• Field of Search: 702/19, 702/23, 600/345, 600/347, 600/365
• US Class Current: 1/1
• CPC Class Codes: A61B 2560/0223 of calibration, e.g. protocols for calibrating sensors
• CPC Class Codes: A61B 2560/0242 adapted to measure environmental factors, e.g. temperature, pollution
• CPC Class Codes: A61B 2560/0276 Determining malfunction
• CPC Class Codes: A61B 5/0008 Temperature signals
• CPC Class Codes: A61B 5/002 Monitoring the patient using a local or closed circuit, e.g. in a room or building A61B5/0017 takes precedence
• CPC Class Codes: A61B 5/0022 Monitoring a patient using a global network, e.g. telephone networks, internet
• CPC Class Codes: A61B 5/1451 for interstitial fluid
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/14546 for measuring analytes not otherwise provided for, e.g. ions, cytochromes
• CPC Class Codes: A61B 5/1473 invasive, e.g. introduced into the body by a catheter A61B5/1482 takes precedence
• CPC Class Codes: A61B 5/1486 using enzyme electrodes, e.g. with immobilised oxidase
• CPC Class Codes: A61B 5/4845 Toxicology, e.g. by detection of alcohol, drug or toxic products A61B5/4848 takes precedence
• CPC Class Codes: A61B 5/7275 Determining trends in physiological measurement data; Predicting development of a medical condition based on physiological measurements, e.g. determining a risk factor
• CPC Class Codes: G16H 15/00 ICT specially adapted for medical reports, e.g. generation or transmission thereof
• CPC Class Codes: G16H 40/63 for local operation

Abstract

Methods and apparatus for providing data processing and control for use in a medical communication system are provided.

Claims

1. A method, comprising:

obtaining signals associated with a monitored analyte level using an analyte sensor comprising a plurality of electrodes including a working electrode including an analyte-responsive enzyme bonded to a polymer disposed on the working electrode;

determining, using one or more processors, a number of corrupt analyte values based on a comparison of the signals associated with the monitored analyte level to a predefined signal range;

dynamically modifying, using the one or more processors, an uncertainty parameter based on the determined number of corrupt analyte values; and

determining an analyte trend information based on the dynamically modified uncertainty parameter.

2. The method of claim 1, wherein the signals are temporally spaced within a predetermined time period.

3. The method of claim 1, wherein the predefined signal range defines a valid signal range.

4. The method of claim 1, wherein the analyte trend information provides a prospective direction of the monitored analyte level.

5. The method of claim 1, wherein the uncertainty parameter is associated with the analyte trend information.

6. The method of claim 1, wherein modifying the uncertainty parameter includes disabling an output of the analyte trend information.

7. The method of claim 6, wherein the output of the analyte trend information is disabled when a predetermined number of the signals are outside the predefined signal range.

8. The method of claim 1, wherein the working electrode comprises a mediator crosslinked with the polymer.

9. An apparatus, comprising:

an analyte sensor comprising a plurality of electrodes including a working electrode including an analyte-responsive enzyme bonded to a polymer disposed on the working electrode, the analyte sensor generating signals associated with a monitored analyte level;

one or more processors operatively coupled to the analyte sensor; and

a memory for storing instructions which, when executed by the one or more processors, causes the one or more processors to determine a number of corrupt analyte values based on a comparison of the signals associated with the monitored analyte level to a predefined signal range, to dynamically modify an uncertainty parameter based on the determined number of corrupt analyte values, and to determine an analyte trend information based on the dynamically modified uncertainty parameter.

10. The apparatus of claim 9, wherein the signals are temporally spaced within a predetermined time period.

11. The apparatus of claim 9, wherein the predefined signal range defines a valid signal range.

12. The apparatus of claim 9, wherein the analyte trend information provides a prospective direction of the monitored analyte level.

13. The apparatus of claim 9, wherein the uncertainty parameter is associated with the analyte trend information.

14. The apparatus of claim 9, wherein modifying the uncertainty parameter includes disabling an output of the analyte trend information.

15. The apparatus of claim 14, wherein the output of the analyte trend information is disabled when a predetermined number of the signals are outside the predefined signal range.

16. The apparatus of claim 9, wherein the working electrode comprises a mediator crosslinked with the polymer.

17. A system, comprising:

a sensor unit including an analyte sensor comprising a plurality of electrodes including a working electrode comprising an analyte-responsive enzyme bonded to a polymer disposed on the working electrode; and

a receiver unit, comprising;

one or more processors; and

a memory for storing instructions which, when executed by the one or more processors, causes the one or more processors to determine a number of corrupt analyte values based on a comparison of signals associated with a monitored analyte level generated by the sensor unit to a predefined signal range, to dynamically modify an uncertainty parameter based on the determined number of corrupt analyte values, and to determine an analyte trend information based on the dynamically modified uncertainty parameter.

18. The system of claim 17, wherein the signals are temporally spaced within a predetermined time period.

19. The system of claim 17, wherein the predefined signal range defines a valid signal range.

20. The system of claim 17, wherein the working electrode comprises a mediator crosslinked with the polymer.