Treatment of circadian rhythm disorders

  • US 9,060,995 B2
  • Filed: 06/11/2014
  • Issued: 06/23/2015
  • Est. Priority Date: 01/26/2012
  • Status: Active Grant
First Claim
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1. A method of entraining a light perception impaired patient suffering from Non-24-Hour Sleep-Wake Disorder to a 24-hour sleep-wake cycle in which the patient awakens at or near a target wake time following a daily sleep period of approximately 7 to 9 hours, wherein the patient is being treated with fluvoxamine, the method comprising:

  • (A) discontinuing the fluvoxamine treatment and then(B) orally treating the patient with 20 mg of tasimelteon once daily before a target bedtime,thereby avoiding the use of tasimelteon in combination with fluvoxamine.

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