Patient monitor for monitoring microcirculation

• US 9,066,666 B2
• Filed: 02/09/2012
• Issued: 06/30/2015
• Est. Priority Date: 02/25/2011
• Status: Active Grant

• Current Assignee: Buntrock Industries Incorporated, Masimo Corporation
• Original Assignee: Cercacor Laboratories
• Inventors: Kiani, Massi Joe E.
• Primary Examiner(s): Winakur, Eric
• Assistant Examiner(s): Fardanesh, Marjan
• Application Number:
  US13/369,773
• Publication Number:
  US 20120265039A1
• Time in Patent Office: 1,237 Days
• Field of Search: 600309-344
• US Class Current: 1/1
• CPC Class Codes: A61B 5/02007 Evaluating blood vessel condition, e.g. elasticity, compliance
• CPC Class Codes: A61B 5/0205 Simultaneously evaluating both cardiovascular conditions and different types of body conditions, e.g. heart and respiratory condition
• CPC Class Codes: A61B 5/026 Measuring blood flow A61B3/1233, A61B3/1241 take precedence
• CPC Class Codes: A61B 5/0261 using optical means, e.g. infrared light
• CPC Class Codes: A61B 5/1455 using optical sensors, e.g. spectral photometrical oximeters
• CPC Class Codes: A61B 5/14551 for measuring blood gases
• CPC Class Codes: A61B 5/14552 Details of sensors specially adapted therefor
• CPC Class Codes: A61B 5/412 Detecting or monitoring sepsis
• CPC Class Codes: A61B 5/6821 Eye
• CPC Class Codes: A61B 5/7271 Specific aspects of physiological measurement analysis A61B5/316, A61B5/349 and A61B5/374 take precedence

Abstract

A patient monitor capable of measuring microcirculation at a tissue site includes a light source, a beam splitter, a photodetector and a patient monitor. Light emitted from the light source is split into a reference arm and a sample arm. The light in the sample arm is directed at a tissue site, such as an eyelid. The reflected light from the tissue site is interfered with the light from the reference arm. The photodetector measures the interference of the light from both the sample arm and the reference arm. The patient monitor uses the measurements from the photodetector to calculate the oxygen saturation at the tissue site and monitor the microcirculation at the tissue site.

Claims

1. A method for monitoring microcirculation in a patient, the method comprising:

emitting one or more beams of light from a light source;

directing the one or more beams of light towards an eyelid of a patient using a beam splitter;

detecting one or more beams of light reflected from the eyelid;

calculating oxygen saturation at the eyelid using the detected one or more beams of light;

calculating a perfusion index at the eyelid using the detected one or more beams of light; and

calculating a flow of blood at the eyelid based at least in part on a ratio of the calculated oxygen saturation and the calculated perfusion index.

2. The method of claim 1, wherein the flow of blood is further calculated using multiple images of the eyelid.

3. The method of claim 1, wherein the flow of blood is further calculated using at least one of ratios of oxygen saturation and ratios of perfusion index.

4. The method of claim 1, further comprising splitting the one or more beams of light into one or more sample arm beams of light and one or more reference arm beams of light, wherein at least one of the sample arm beams of light is directed towards the eyelid and the one or more reference arm beams of light is directed towards a reflector.

5. The method of claim 4, wherein optical interference between reflected one or more reference arm beams of light and reflected one or more sample arm beams of light is used to calculate the flow of blood at the eyelid.

6. The method of claim 1, wherein the light source comprises a first emitter that emits light at an approximately red wavelength, and a second light emitter that emits light at an approximately infrared wavelength.

7. The method of claim 1, wherein the perfusion index is calculated based at least on a ratio of infrared light and the oxygen saturation is calculated based at least on a ratio of red light and infrared light.

8. The method of claim 1, further comprising causing one or more displays to display the calculated flow of blood.

9. The method of claim 1, further comprising:

determining that the calculated flow of blood does not satisfy a predetermined threshold; and

activating an alarm based at least in part on said determining.

10. A microcirculation monitoring device configured to monitor the microcirculation of a patient at an eyelid, the monitoring device comprising:

a light source configured to emit one or more beams of light;

a beam splitter configured to direct at least one beam of light from of the one or more beams of light towards an eyelid, wherein the at least one beam interacts with the eyelid;

a detector configured to detect one or more beams of light reflected from the eyelid; and

a patient monitor configured to;

calculate an oxygen saturation using the detected one or more beams of light;

calculate a perfusion index using the detected one or more beams of light; and

calculate a flow of blood at the eyelid based at least in part on a ratio of the calculated oxygen saturation and the calculated perfusion index.

11. The monitoring device of claim 10, wherein the patient monitor is further configured to calculate the flow of blood using multiple images of the eyelid.

12. The monitoring device of claim 10, wherein the patient monitor is further configured to calculate the flow of blood using at least one of ratios of oxygen saturation and ratios of perfusion index.

13. The monitoring device of claim 10, wherein the beam splitter splits the beams of light into one or more sample arm beams of light and one or more reference arm beams of light, wherein at least one of the sample arm beams of light is directed towards the eyelid and the one or more reference arm beams of light is directed towards a reflector.

14. The monitoring device of claim 13, wherein optical interference between reflected one or more reference arm beams of light and reflected one or more sample arm beams of light is used to calculate the flow of blood at the eyelid.

15. The monitoring device of claim 10, wherein the perfusion index is calculated based at least on a ratio of infrared light and the oxygen saturation is calculated based at least on a ratio of red light and infrared light.

16. The monitoring device of claim 10, wherein the patient monitor is further configured to cause one or more displays to display the calculated flow of blood.

17. The monitoring device of claim 10, wherein the patient monitor is further configured to activate an alarm based at least in part on a determination that the calculated flow of blood does not satisfy a predetermined threshold.