Composition and method for treating neurological disease

  • US 9,072,697 B2
  • Filed: 01/07/2015
  • Issued: 07/07/2015
  • Est. Priority Date: 11/24/2004
  • Status: Active Grant
First Claim
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1. A method comprising:

  • orally administering to a human subject with Parkinson'"'"'s disease once-daily a composition consisting of(i) a drug selected from the group consisting of amantadine and pharmaceutically acceptable salts thereof, and(ii) at least one excipient,wherein at least 50% of the drug in the composition is in an extended release form, andwherein the composition has an in vitro dissolution profile ranging between 35% and 55% in 2 hours, 60% and 80% in 4 hours, and greater than 90% in 8 hours using a USP type 2 (paddle) dissolution system at 50 rpm at a temperature of 37±

    0.5°

    C. in water, andwherein the daily dose of drug administered to the human subject is 200 to 500 mg.

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