Flow directional infusion device

  • US 9,089,668 B2
  • Filed: 09/12/2012
  • Issued: 07/28/2015
  • Est. Priority Date: 09/28/2011
  • Status: Active Grant
First Claim
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1. A flow directional infusion device for reducing reflux of an agent in an infusate in a vessel during a therapy procedure, comprises:

  • a) a catheter having a proximal portion and a distal portion with a distal end; and

    b) a composite filter valve located at said distal portion of said catheter, said filter valve having a proximal end fixed to said catheter, and a distal end, said filter valve comprising,i) a plurality of elongate polymeric first filaments provided in a braid and together defining a valve, each of said first filaments having a diameter of 0.025 mm to 0.127 mm, said first filaments having a proximal end, a distal end, and a length extending between the proximal and distal ends of the said first filaments, said proximal ends of said first filaments secured relative to each other,said valve fully collapsible into an undeployed state, and expandable from said undeployed state into a radially-expanded deployed state by a spring bias of said first filaments, said first filaments extending relative to each other in said braid in a non-bonded state such that they are movable relative to each other as said valve moves from said undeployed state to said deployed state,wherein in said deployed state said first filaments cross one another within said braid at an angle of 100°

    to 150°

    , and said first filaments have a Young'"'"'s modulus of elasticity greater than 100 MPa, andii) a filter formed by polymeric second filaments that are integrated with said valve by electrostatically depositing or spinning said second filaments onto the first filaments, said filter defining a pore size not exceeding 500 μ

    m,wherein said filter valve expands from said undeployed state to said deployed state in less than one second in an at-rest fluid having a viscosity of 3.2 cP,wherein once said filter valve is in said deployed state in the vessel, said filter valve is dynamically movable within the vessel between an expanded valve-open configuration and a collapsed valve-closed configuration depending on local biological fluid flow conditions about said filter valve, and when said filter valve is in said valve-open configuration, said pore size of said filter renders said filter impermeable to the agent of the infusate, andsaid filter valve having a circumferential wall defining an opening located proximal of said distal end of said filter valve for transfer of the infusate from a location within said catheter, through said opening in said circumferential wall of said filter so as to exit the filter valve in a radially non-uniform manner, and to deliver the infusate from said filter valve into the vessel at a location proximal said distal end of said filter valve.

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