Tamper resistant dosage forms

  • US 9,095,614 B2
  • Filed: 10/16/2014
  • Issued: 08/04/2015
  • Est. Priority Date: 08/25/2006
  • Status: Active Grant
First Claim
Patent Images

1. A method of treating pain comprising administering to a patient in need thereof a cured shaped tablet comprising an extended release matrix comprising a composition, wherein said tablet comprises:

  • (1) an opioid or a pharmaceutically acceptable salt thereof,(2) at least one low molecular weight polyethylene oxide having, based on rheological measurements, an approximate molecular weight of less than 1,000,000, and(3) at least one high molecular weight polyethylene oxide having, based on rheological measurements, an approximate molecular weight of 7,000,000;

    wherein said tablet is prepared by a process comprising the steps of;

    (a) combining said opioid or pharmaceutically acceptable salt thereof with each of said low molecular weight polyethylene oxide and said high molecular weight polyethylene oxide to form at least one blend;

    (b) applying each said blend to form a shaped tablet; and

    (c) curing said shaped tablet by subjecting the shaped tablet to a temperature from about 60 to about 90°

    C. for a time of from about 15 minutes to about 10 hours,wherein said cured shaped tablet comprises a once-a-day dosage form having at least 79% by weight, based upon the total weight of said composition, of the total combined weight of said high and low molecular weight polyethylene oxides.

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