Composition and method for the diagnosis and treatment of diseases associated with neurite degeneration
First Claim
Patent Images
1. An isolated antibody the antibody comprising:
- (a) a variable heavy domain comprising a complementarity-determining region (CDR) 1 comprising an amino acid sequence as set forth in SEQ ID NO;
2, a CDR2 comprising an amino acid sequence as set forth in SEQ ID NO;
3, and a CDR3 comprising an amino acid sequence as set forth in SEQ ID NO;
4, and a variable light domain comprising a CDR1 comprising an amino acid sequence as set forth in SEQ ID NO;
6, a CDR2 comprising an amino acid sequence as set forth in SEQ ID NO;
7, and a CDR3 comprising an amino acid sequence as set forth in SEQ ID NO;
73;
or(b) a light chain variable amino acid sequence as set forth in SEQ ID NO;
146 and a heavy chain variable amino acid sequence as set forth in SEQ ID NO;
147,wherein the antibody binds to Repulsive Guidance Molecule a (RGMa), wherein the antibody is selected from the group consisting of a human antibody, a monoclonal antibody, an affinity matured, a chimeric antibody and a humanized antibody.
0 Assignments
0 Petitions
Accused Products
Abstract
Provided herein are antibodies that bind to Repulsive Guidance Molecule a (RGMa) and methods of using the antibodies to treat and diagnose neurite degenerative diseases and disorders.
279 Citations
5 Claims
-
1. An isolated antibody the antibody comprising:
-
(a) a variable heavy domain comprising a complementarity-determining region (CDR) 1 comprising an amino acid sequence as set forth in SEQ ID NO;
2, a CDR2 comprising an amino acid sequence as set forth in SEQ ID NO;
3, and a CDR3 comprising an amino acid sequence as set forth in SEQ ID NO;
4, and a variable light domain comprising a CDR1 comprising an amino acid sequence as set forth in SEQ ID NO;
6, a CDR2 comprising an amino acid sequence as set forth in SEQ ID NO;
7, and a CDR3 comprising an amino acid sequence as set forth in SEQ ID NO;
73;
or(b) a light chain variable amino acid sequence as set forth in SEQ ID NO;
146 and a heavy chain variable amino acid sequence as set forth in SEQ ID NO;
147,wherein the antibody binds to Repulsive Guidance Molecule a (RGMa), wherein the antibody is selected from the group consisting of a human antibody, a monoclonal antibody, an affinity matured, a chimeric antibody and a humanized antibody. - View Dependent Claims (2, 3, 4, 5)
-
Specification