Drug-delivery pumps and methods of manufacture

• US 9,107,995 B2
• Filed: 06/07/2013
• Issued: 08/18/2015
• Est. Priority Date: 05/08/2008
• Status: Expired due to Fees

• Current Assignee: MiniPumps, LLC
• Original Assignee: MiniPumps, LLC
• Inventors: Pang, Changlin, Jiang, Fukang, Shih, Jason, Caffey, Sean, Humayun, Mark S., Tai, Yu-Chong
• Primary Examiner(s): ALANKO, ANITA KAREN
• Application Number:
  US13/912,562
• Publication Number:
  US 20130276974A1
• Time in Patent Office: 802 Days
• Field of Search: None
• US Class Current: 1/1
• CPC Class Codes: A61F 9/0017 implantable in, or in contact with, the eye, e.g. ocular inserts
• CPC Class Codes: A61F 9/00781 Apparatus for modifying intraocular pressure, e.g. for glaucoma treatment drainage implants in general A61M27/002
• CPC Class Codes: A61M 2005/14204 with gas-producing electrochemical cell
• CPC Class Codes: A61M 2005/14264 with means for compensating influence from the environment
• CPC Class Codes: A61M 2205/0244 Micromachined materials, e.g. made from silicon wafers, microelectromechanical systems [MEMS] or comprising nanotechnology
• CPC Class Codes: A61M 2210/0612 Eyes
• CPC Class Codes: A61M 39/24 Check- or non-return valves
• CPC Class Codes: A61M 5/1408 in parallel, e.g. manifolds, sequencing valves access sites A61M39/02; tube connectors A61M39/10
• CPC Class Codes: A61M 5/142 Pressure infusion, e.g. using pumps
• CPC Class Codes: A61M 5/14276 specially adapted for implantation
• CPC Class Codes: A61M 5/14593 the diaphragm being actuated by fluid pressure
• CPC Class Codes: A61M 5/16886 for measuring fluid flow rate, i.e. flowmeters
• CPC Class Codes: B44C 1/227 by etching
• CPC Class Codes: Y10T 156/1092 All laminae planar and face to face
• CPC Class Codes: Y10T 156/1093 with covering of discrete laminae with additional lamina

Abstract

Embodiments of method of manufacturing an implantable pump, including providing an upper layer comprising a dome structure for housing a drug chamber and a cannula in fluid communication with the drug chamber, providing a middle deflection layer adjacent the drug chamber, providing a bottom layer comprising electrolysis electrodes, and bonding the upper layer, middle deflection layer, and bottom layer to form the pump.

Claims

1. A method of manufacturing an implantable pump, the method comprising:

providing an upper layer comprising a dome structure for housing a drug chamber and a cannula in fluid communication with the drug chamber;

providing a middle deflection layer adjacent the drug chamber;

providing a bottom layer comprising a permeable membrane; and

thermally bonding the upper layer, middle deflection layer, and bottom layer to form the pump.

2. The method of claim 1, wherein the bottom layer is formed according to steps comprising:

coating a first photoresist layer onto a silicon substrate as a sacrificial layer;

depositing a first parylene layer onto the first photoresist layer to form a first layer of the bottom layer;

depositing a second photoresist layer over the first parylene layer and patterning the second photoresist layer;

depositing a second parylene layer over the second photoresist layer;

etching the second parylene layer; and

removing the photoresist layers, thereby leaving the bottom layer.

3. The method of claim 1, wherein (i) the portions of the bottom layer comprising only the first parylene layer are at least partially permeable, and (ii) the portions of the bottom layer comprising both the first and second parylene layers are substantially impermeable.

4. The method of claim 1, further comprising a substantially rigid spacer comprising a refill hole.