Method and system for non-invasive assessment of coronary artery disease
First Claim
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1. A method for assessment of coronary artery disease based on medical image data comprising:
- generating an anatomical model of a coronary artery from medical image data;
estimating a velocity of blood in the coronary artery based on a spatio-temporal representation of contrast agent propagation over a length of the coronary artery in the medical image data, wherein estimating a velocity of blood in the coronary artery comprises;
estimating a maximum velocity of blood on a cross-section of the coronary artery based on the spatio-temporal representation of contrast agent propagation over the length of the coronary artery in the medical image data, andmapping the maximum velocity of the blood on the cross-section of the coronary artery to an average velocity representing a spatial average of a velocity profile over the cross-section of the coronary artery using patient-specific mapping parameters; and
simulating blood flow in the anatomical model of the coronary artery using a computational fluid dynamics (CFD) simulation using the estimated velocity of the blood in the coronary artery as a boundary condition.
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Abstract
In order to assess coronary artery disease from medical image data, an anatomical model of a coronary artery is generated from the medical image data. A velocity of blood in the coronary artery is estimated based on a spatio-temporal representation of contrast agent propagation in the medical image data. Blood flow is simulated in the anatomical model of the coronary artery using a computational fluid dynamics (CFD) simulation using the estimated velocity of the blood in the coronary artery as a boundary condition.
41 Citations
28 Claims
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1. A method for assessment of coronary artery disease based on medical image data comprising:
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generating an anatomical model of a coronary artery from medical image data; estimating a velocity of blood in the coronary artery based on a spatio-temporal representation of contrast agent propagation over a length of the coronary artery in the medical image data, wherein estimating a velocity of blood in the coronary artery comprises; estimating a maximum velocity of blood on a cross-section of the coronary artery based on the spatio-temporal representation of contrast agent propagation over the length of the coronary artery in the medical image data, and mapping the maximum velocity of the blood on the cross-section of the coronary artery to an average velocity representing a spatial average of a velocity profile over the cross-section of the coronary artery using patient-specific mapping parameters; and simulating blood flow in the anatomical model of the coronary artery using a computational fluid dynamics (CFD) simulation using the estimated velocity of the blood in the coronary artery as a boundary condition. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16)
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17. An apparatus for assessment of coronary artery disease based on medical image data comprising:
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means for generating an anatomical model of a coronary artery from medical image data; means for estimating a velocity of blood in the coronary artery based on a spatio-temporal representation of contrast agent propagation over a length of the coronary artery in the medical image data, wherein the means for estimating a velocity of blood in the coronary artery comprises; means for estimating a maximum velocity of blood on a cross-section of the coronary artery based on the spatio-temporal representation of contrast agent propagation over the length of the coronary artery in the medical image data, means for mapping the maximum velocity of the blood on the cross-section of the coronary artery to an average velocity representing a spatial average of a velocity profile over the cross-section of the coronary artery using patient-specific mapping parameters; and means for simulating blood flow in the anatomical model of the coronary artery using a computational fluid dynamics (CFD) simulation using the estimated velocity of the blood in the coronary artery as a boundary condition. - View Dependent Claims (18, 19, 20, 21, 22)
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23. A non-transitory computer readable medium encoded with computer executable instructions for assessment of coronary artery disease based on medical image data, the computer executable instructions defining steps comprising:
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generating an anatomical model of a coronary artery from medical image data; estimating a velocity of blood in the coronary artery based on a spatio-temporal representation of contrast agent propagation over a length of the coronary artery in the medical image data, wherein estimating a velocity of blood in the coronary artery comprises; estimating a maximum velocity of blood on a cross-section of the coronary artery based on the spatio-temporal representation of contrast agent propagation over the length of the coronary artery in the medical image data, and mapping the maximum velocity of the blood on the cross-section of the coronary artery to an average velocity representing a spatial average of a velocity profile over the cross-section of the coronary artery using patient-specific mapping parameters; and simulating blood flow in the anatomical model of the coronary artery using a computational fluid dynamics (CFD) simulation using the estimated velocity of the blood in the coronary artery as a boundary condition. - View Dependent Claims (24, 25, 26, 27, 28)
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Specification