Methods and compositions for administration of oxybutynin
First Claim
1. A method for treating pulmonary disease comprising delivering directly to a patient'"'"'s lungs a therapeutically effective amount of a salt form of oxybutynin in combination with one or more pharmaceutically effective agents, wherein the salt form of oxybutynin is selected from the group consisting of a xinafoate salt and a laurate salt, and wherein, the oxybutynin and the pharmaceutically effective agents are delivered in dry powder form using a dry powder inhaler, wherein the dosage of the therapeutically effective amount of oxybutynin is within the range of 0.001 to 20 mg per day, 0.02 to 15 mg per day, or 0.05 to 10 mg per day administered as needed.
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Abstract
The present invention is directed to methods and compositions for treating pulmonary disease comprising delivering directly to a patient'"'"'s lungs a therapeutically effective amount of oxybutynin in combination with one or more pharmaceutically effective agents. Oxybutynin may be selected from the group consisting of, but not limited to, a xinafoate salt, a palmitate salt, a pamoic salt, a resonate salt, a laurate salt and other salts. The pharmaceutically effective agents comprise bronchodilators, antiinflammatories, corticosteroids, corticosteroid reversal agent or alveolar growth agents or other agents selected from proteinase or protease inhibitors.
88 Citations
6 Claims
- 1. A method for treating pulmonary disease comprising delivering directly to a patient'"'"'s lungs a therapeutically effective amount of a salt form of oxybutynin in combination with one or more pharmaceutically effective agents, wherein the salt form of oxybutynin is selected from the group consisting of a xinafoate salt and a laurate salt, and wherein, the oxybutynin and the pharmaceutically effective agents are delivered in dry powder form using a dry powder inhaler, wherein the dosage of the therapeutically effective amount of oxybutynin is within the range of 0.001 to 20 mg per day, 0.02 to 15 mg per day, or 0.05 to 10 mg per day administered as needed.
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6. A method for treating chronic obstructive pulmonary disease comprising delivering directly to a patient'"'"'s lungs a therapeutically effective amount of a salt form of oxybutynin in combination with one or more pharmaceutically effective agents, wherein the salt form of oxybutynin is selected from the group consisting of a xinafoate salt and a laurate salt, and wherein, the oxybutynin and the pharmaceutically effective agents are delivered in dry powder form using a dry powder inhaler.
Specification