1-[2-(2,4-dimethylphenylsulfanyl)-phenyl]piperazine as a compound with combined serotonin reuptake, 5-HT;and 5-HT;activity for the treatment of cognitive impairment

  • US 9,125,908 B2
  • Filed: 04/01/2014
  • Issued: 09/08/2015
  • Est. Priority Date: 06/16/2006
  • Status: Active Grant
First Claim
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1. A method of treating cognitive impairment involving decline in speed of processing, executive function, attention, or verbal learning and memory in a patient diagnosed with depression, the method comprising:

  • administering a therapeutically effective amount of Compound I or a pharmaceutically acceptable salt thereof to the patient,wherein Compound I is 1-[2-(2,4-dimethylphenylsulfanyl)-phenyl]piperazine, Compound I or a pharmaceutically acceptable salt thereof is crystalline and is administered at a daily dose of 1-20 mg, and the method alleviates a symptom or complication of the cognitive impairment or delays the progression of the cognitive impairment.

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