Breast implant with covering, analyte sensors and internal power source

• US 9,144,489 B2
• Filed: 06/13/2012
• Issued: 09/29/2015
• Est. Priority Date: 06/13/2012
• Status: Expired due to Fees

• Current Assignee: Elwha LLC (Intellectual Ventures LLC)
• Original Assignee: Elwha LLC (Intellectual Ventures LLC)
• Inventors: Boyden, Edward S., Della Rocca, Gregory J., Hawkins, Daniel, Hyde, Roderick A., Langer, Robert, Leuthardt, Eric C., Myckatyn, Terence, Parikh, Parag Jitendra, Rivet, Dennis J., Shimony, Joshua S., Smith, Michael A., Sweeney, Elizabeth A., Tegreene, Clarence T.
• Primary Examiner(s): Sweet, Thomas J
• Assistant Examiner(s): Schutte, Wade P
• Application Number:
  US13/495,275
• Publication Number:
  US 20130338770A1
• Time in Patent Office: 1,203 Days
• Field of Search: 623/8
• US Class Current: 1/1
• CPC Class Codes: A61B 5/076 Permanent implantations telemetry using implanted circuitry A61B5/0031; implanted stimulators for therapy A61N1/3605, A61N1/362, A61N1/372
• CPC Class Codes: A61B 5/14503 invasive, e.g. introduced into the body by a catheter or needle or using implanted sensors A61B5/1459, A61B5/1464, A61B5/1473, A61B5/1482, A61B5/14865 take precedence
• CPC Class Codes: A61B 5/1451 for interstitial fluid
• CPC Class Codes: A61B 5/14542 for measuring blood gases A61B5/14551 takes precedence
• CPC Class Codes: A61B 5/14546 for measuring analytes not otherwise provided for, e.g. ions, cytochromes
• CPC Class Codes: A61B 5/14735 comprising an immobilised reagent
• CPC Class Codes: A61F 2/12 Mammary prostheses and implants

Abstract

Breast implants including sensor modules and related methods are described herein. Breast implants include those with: a shell configured to be substantially filled with a viscous material; at least one fluid-permeable cover, the cover completely enveloping the shell; a plurality of sensor modules attached to the shell, the sensor modules oriented to detect one or more analytes in a fluid between the shell and the cover, the sensor modules positioned at a distance from each other, wherein each of the plurality of sensor modules includes a unique identifier; and at least one power source operably attached to the plurality of sensor modules.

Claims

1. A breast implant comprising:

a shell configured to be filled with a viscous material;

at least one fluid-permeable cover, the cover completely enveloping the shell and defining a gap between the shell and the cover into which a bodily fluid is permitted to pass;

a plurality of sensor modules attached to the shell, the sensor modules oriented to detect one or more analytes indicative of abnormal cellular growth in the bodily fluid between the shell and the cover in the gap, the sensor modules positioned at a distance from each other, wherein each of the plurality of sensor modules includes a unique identifier; and

at least one power source operably attached to the plurality of sensor modules.

2. The breast implant of claim 1, wherein the at least one fluid-permeable cover comprises:

a mesh structure.

3. The breast implant of claim 1, wherein the at least one fluid-permeable cover comprises:

an analyte-permeable cover.

4. The breast implant of claim 1, wherein the at least one fluid-permeable cover comprises:

a porous structure.

5. The breast implant of claim 1, wherein the at least one fluid-permeable cover comprises:

a membrane.

6. The breast implant of claim 1, wherein the gap is a uniform gap between the cover and the shell.

7. The breast implant of claim 1, wherein the plurality of sensor modules attached to the shell comprise:

at least one sensor module configured to detect at least two analytes in the bodily fluid between the shell and the cover in the gap, wherein the at least two analytes are of different types.

8. The breast implant of claim 1, wherein the plurality of sensor modules attached to the shell comprise at least one of:

a cantilever-based sensor, a chemiresistor, an enzyme-based sensor, a voltammetric sensor, a field-effect transistor, or an optical-based sensor.

9. The breast implant of claim 1, wherein the unique identifier for each of the plurality of sensor modules comprises:

an alphanumeric code.

10. The breast implant of claim 1, wherein the unique identifier for each of the plurality of sensor modules comprises:

a positional identifier.

11. The breast implant of claim 1, wherein the at least one power source is configured to be rechargeable.

41. The breast implant of claim 1, wherein the at least one fluid-permeable cover includes a fluid control film component oriented to permit directional flow of the bodily fluid into and out of the gap.

12. A breast implant comprising:

a shell configured to be filled with a viscous material;

at least one fluid-permeable cover, the cover completely enveloping the shell and defining a gap between the shell and the cover into which a bodily fluid is permitted to pass;

a plurality of sensor modules attached to the shell, wherein each of the plurality of sensor modules includes a unique identifier, each of the plurality of sensor modules oriented to detect one or more analytes indicative of abnormal cell growth in the bodily fluid between the shell and the cover in the gap;

at least one processor operably attached to the plurality of sensor modules; and

at least one power source operably attached to the at least one processor.

13. The breast implant of claim 12, wherein the at least one fluid-permeable cover comprises:

a mesh-structure.

14. The breast implant of claim 12, wherein the at least one fluid-permeable cover comprises:

an analyte-permeable cover.

15. The breast implant of claim 12, wherein the at least one fluid-permeable cover comprises:

a porous structure.

16. The breast implant of claim 12, wherein the at least one fluid-permeable cover comprises:

a membrane.

17. The breast implant of claim 12, wherein the gap is a uniform gap between the at least one fluid-permeable cover and the shell.

18. The breast implant of claim 12, wherein the plurality of sensor modules attached to the shell comprise:

at least one sensor module configured to detect at least two analytes in the bodily fluid between the shell and the cover in the gap, wherein the at least two analytes are of different types.

19. The breast implant of claim 12, wherein the plurality of sensor modules attached to the shell comprise:

at least two sensor types in each sensor module.

20. The breast implant of claim 12, wherein the plurality of sensor modules attached to the shell comprise at least one of:

a cantilever-based sensor, a chemiresistor, an enzyme-based sensor, a voltammetric sensor, a field-effect transistor, or an optical-based sensor.

21. The breast implant of claim 12, wherein the unique identifier for each of the plurality of sensor modules comprises:

an alphanumeric code.

22. The breast implant of claim 12, wherein the unique identifier for each of the plurality of sensor modules comprises:

a positional identifier.

23. The breast implant of claim 12, wherein the at least one power source is configured to be rechargeable.

24. The breast implant of claim 12, wherein there are a plurality of processors, each processor attached to one of the plurality of sensor modules.

25. A breast implant comprising:

a shell configured to be filled with a viscous material;

at least one fluid-permeable cover, the cover completely enveloping the shell and defining a gap between the shell and the cover into which a bodily fluid is permitted to pass;

a plurality of sensor modules attached to the shell, the sensor modules oriented to detect one or more analytes indicative of abnormal cellular growth in the bodily fluid between the shell and the cover in the gap and wherein each of the plurality of sensor modules includes a unique identifier;

at least one processor operably attached to the plurality of sensor modules;

at least one power source operably attached to the at least one processor; and

at least one transmission unit operably attached to the at least one processor.

26. The breast implant of claim 25, wherein the at least one fluid-permeable cover comprises:

a mesh structure.

27. The breast implant of claim 25, wherein the at least one fluid-permeable cover comprises:

an analyte-permeable cover.

28. The breast implant of claim 25, wherein the at least one fluid-permeable cover comprises:

a porous structure.

29. The breast implant of claim 25, wherein the at least one fluid-permeable cover comprises:

a membrane.

30. The breast implant of claim 25, wherein the gap is a uniform gap between the at least one fluid-permeable cover and the shell.

31. The breast implant of claim 25, wherein the plurality of sensor modules attached to the shell comprise:

at least one sensor module configured to detect at least two analytes in the bodily fluid between the shell and the cover in the gap, wherein the at least two analytes are of different types.

32. The breast implant of claim 25, wherein the plurality of sensor modules attached to the shell comprise at least one of:

a cantilever-based sensor, a chemiresistor, an enzyme-based sensor, a voltammetric sensor, a field-effect transistor, or an optical-based sensor.

33. The breast implant of claim 25, wherein the unique identifier for each of the plurality of sensor modules comprises:

an alphanumeric code.

34. The breast implant of claim 25, wherein the unique identifier for each of the plurality of sensor modules comprises:

a positional identifier.

35. The breast implant of claim 25, wherein the at least one power source is configured to be rechargeable.

36. The breast implant of claim 25, wherein the at least one transmission unit comprises:

a radio-frequency transmitter.

37. The breast implant of claim 25, wherein the at least one transmission unit comprises:

an infrared transmitter.

38. A breast implant comprising:

a shell configured to be filled with a viscous material;

at least one fluid-permeable cover, the cover completely enveloping the shell and defining a gap between the shell and the cover into which a bodily fluid is permitted to pass;

a plurality of sensor modules attached to the shell, the sensor modules configured to detect one or more biological analytes in the bodily fluid between the shell and the cover in the gap, the one or more biological analytes indicative of abnormal cellular growth arising from biological tissue;

at least one transmission unit attached to the plurality of sensor modules; and

at least one power source attached to the plurality of sensor modules and to the transmission unit.

39. The breast implant of claim 38, wherein the plurality of sensor modules are positioned on the shell with a distance between the sensor modules.

40. The breast implant of claim 38, comprising:

at least one switch attached to both the at least one transmission unit and the plurality of sensor modules, the at least one switch configured to activate the transmission unit in response to a signal from one or more of the sensor modules.