Systems, apparatuses, and methods for treating tissue and controlling stenosis

• US 9,149,328 B2
• Filed: 11/11/2010
• Issued: 10/06/2015
• Est. Priority Date: 11/11/2009
• Status: Active Grant

• Current Assignee: Nuvaira, Inc.
• Original Assignee: Holaira, Inc. (Nuvaira, Inc.)
• Inventors: Dimmer, Steven C., Mayse, Martin L., Deem, Mark, Gifford, Hanson S. III
• Primary Examiner(s): Gedeon, Brian T
• Application Number:
  US13/509,581
• Publication Number:
  US 20120310233A1
• Time in Patent Office: 1,790 Days
• Field of Search: None
• US Class Current: 1/1
• CPC Class Codes: A61B 18/1477 Needle-like probes
• CPC Class Codes: A61B 18/1492 having a flexible, catheter-like structure, e.g. for heart ablation A61B18/1477 takes precedence
• CPC Class Codes: A61B 2018/00005 Cooling or heating of the probe or tissue immediately surrounding the probe
• CPC Class Codes: A61B 2018/00011 with fluids
• CPC Class Codes: A61B 2018/0016 Energy applicators arranged in a two- or three dimensional array
• CPC Class Codes: A61B 2018/00214 Expandable means emitting energy, e.g. by elements carried thereon
• CPC Class Codes: A61B 2018/0022 Balloons
• CPC Class Codes: A61B 2018/00267 having a basket shaped structure
• CPC Class Codes: A61B 2018/00434 Neural system
• CPC Class Codes: A61B 2018/00541 Lung or bronchi
• CPC Class Codes: A61B 2018/1435 Spiral
• CPC Class Codes: A61B 2018/1467 using more than two electrodes on a single probe
• CPC Class Codes: A61B 2018/1475 Electrodes retractable in or deployable from a housing
• CPC Class Codes: A61N 2007/003 Destruction of nerve tissue
• CPC Class Codes: A61N 7/022 intracavitary

Abstract

Systems, delivery devices, and methods to treat to ablate, damage, or otherwise affect tissue. The treatment systems are capable of delivering a coolable ablation assembly that ablates targeted tissue without damaging non-targeted tissue. The coolable ablation assembly damages nerve tissue to temporarily or permanently decrease nervous system input. The system, delivery devices, and methods can damage tissue and manage scarring and stenosis.

Claims

1. A method of treating a subject, comprising:

positioning an ablation assembly with respect to an airway of the subject, wherein the ablation assembly comprises a plurality of energy emitting elements spaced circumferentially about from each other about and axially from each other along a longitudinal axis of the ablation assembly; and

causing energy to be emitted from the ablation assembly to target regions of the airway to create a plurality of axially spaced apart discrete lesions, each lesion extending only partially around a circumference of the airway, wherein an arc length about the circumference of at least one lesion at least partially overlaps with an arc length about the circumference of at least one other lesion of the plurality of lesions.

2. The method of claim 1, further comprising causing tissue to be heated at a depth greater than about 2 mm to cause cell death while maintaining tissues at a depth less than 2 mm in the airway wall at a temperature below that at which cell death occurs.

3. The method of claim 1, further comprising causing coolant to be delivered through the ablation assembly to cool tissues of the airway at a depth less than 2 mm.

4. A method of treating a subject, comprising:

moving an energy emitter of a delivery device along an airway of the subject, wherein the energy emitter comprises a plurality of energy emitting electrodes spaced circumferentially and axially from each other along a longitudinal axis of the ablation assembly;

positioning at least one electrode of the energy emitter between cartilaginous rings of the airway; and

causing energy to be emitted from the at least one electrode to target regions of the airway at axially separated locations along a long axis of the airway to form a plurality of inter-cartilaginous lesions, each lesion extending only partially around a circumference of the airway, and wherein at least some of the lesions overlap circumferentially about a long axis of the airway.

5. The method of claim 4, further comprising causing the wall of the airway to be cooled to protect interior tissue of the airway.

6. The method of claim 4, wherein one of the lesions lies in a first imaginary plane orthogonal to the long axis of the airway and the another lesion lies in a second imaginary plane orthogonal to the long axis of the airway, wherein the first imaginary plane and the second imaginary plane are axially spaced apart along the long axis of the airway.

7. The method of claim 4, further comprising causing a wall of the airway to be cooled while causing the energy to be emitted to limit or prevent cell death in tissue located between a nerve trunk and the energy emitter.

8. The method of claim 4, further comprising causing tissue to be heated at a depth of at least about 2 mm to cause cell death while maintaining tissues at a depth less than 2 mm in the airway wall at a temperature below that at which cell death occurs.

9. The method of claim 4, further comprising causing coolant to be delivered through the electrode while causing energy to be emitted from the electrode.

10. A method of treating tissue, comprising:

positioning an ablation assembly in a lumen of an airway of a subject, wherein the ablation assembly comprises a plurality of electrodes spaced circumferentially and axially from each other along a longitudinal axis of the ablation assembly; and

causing energy to be delivered to tissue of the airway using e the plurality of electrodes of the ablation assembly positioned near an inner surface of the airway, wherein the energy damages target regions axially separated along the airway thereby defining lesions having a maximum cross-sectional width radially spaced from the inner surface of the airway.

11. The method of claim 10, further comprising positioning the plurality of the electrodes between cartilaginous rings while causing energy to be delivered.

12. The method of claim 10, further comprising causing energy to be delivered to form at least one helical-shaped lesion or spiral-shaped lesion.

13. The method of claim 10, wherein the maximum cross-sectional width of at least one target region is at a depth at least 2 mm from the inner surface of the airway contacting the ablation assembly.

14. The method of claim 10, further comprising causing tissue to be damaged at one of the target regions such that the cross-sectional width of the damaged tissue is maximized at a depth deeper than a region of smooth muscle tissue in the tissue.

15. The method of claim 10, wherein causing energy to be delivered comprises damaging at least one target region such that a majority of that target region is outside a region of smooth muscle tissue of the tissue.

16. The method of claim 15, wherein most of a volume of the damaged tissue is outside of a region of smooth muscle tissue.

17. A method for treating a subject, comprising:

positioning an ablation assembly within an airway of the subject, wherein the ablation assembly comprises a plurality of energy emitting elements spaced circumferentially and axially from each other along a longitudinal axis of the ablation assembly; and

causing energy to be delivered from the ablation assembly to form a plurality of lesions, each lesion being axially offset with respect to one another in a direction of a long axis of the airway, wherein each lesion is at least partially adjacent to or overlaps another lesion in a circumferential direction of the airway.

18. The method of claim 17, wherein each lesion is separated by a distance of at least 5 mm as measured along the long axis of the ablation assembly.

19. The method of claim 17, further comprising causing energy to be delivered to form a continuous lesion that has a spiral shape or a helical shape.

20. The method of claim 17, further comprising causing a discontinuous lesion to be formed, the lesion having a spiral shape or a helical shape.

21. The method of claim 17, wherein the at least one lesion comprises a plurality of spaced apart lesions positioned about the airway.