Method of treating middle ear infections

  • US 9,149,486 B2
  • Filed: 08/25/2014
  • Issued: 10/06/2015
  • Est. Priority Date: 09/21/2001
  • Status: Active Grant
First Claim
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1. A method of treating a middle ear infection in a human patient comprising the steps of:

  • (a) diagnosing the patient as having otitis media and an open tympanic membrane in at least one ear; and

    (b) topically applying into the ear canal of the patient'"'"'s ear an aqueous suspension composition containing a combination of ciprofloxacin and dexamethasone, wherein the composition comprisesa) 0.01-0.5% (wt.) dexamethasone, wherein the dexamethasone has an average particle size on a mean volume basis of less than 10 μ


    b) 0.1-0.4% (wt.) ciprofloxacin;

    c) 0.1-0.9% (wt.) tonicity agent;

    d) 0.01-0.2% (wt.) of a nonionic surfactant;

    e) a buffer; and

    wherein the composition has a pH from about 3-5.

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