Method of treating middle ear infections
DCFirst Claim
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1. A method of treating a middle ear infection in a human patient comprising the steps of:
- (a) diagnosing the patient as having otitis media and an open tympanic membrane in at least one ear; and
(b) topically applying into the ear canal of the patient'"'"'s ear an aqueous suspension composition containing a combination of ciprofloxacin and dexamethasone, wherein the composition comprisesa) 0.01-0.5% (wt.) dexamethasone, wherein the dexamethasone has an average particle size on a mean volume basis of less than 10 μ
M;
b) 0.1-0.4% (wt.) ciprofloxacin;
c) 0.1-0.9% (wt.) tonicity agent;
d) 0.01-0.2% (wt.) of a nonionic surfactant;
e) a buffer; and
wherein the composition has a pH from about 3-5.
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Abstract
Aqueous suspension formulations containing dexamethasone and ciprofloxacin are disclosed for the treatment of middle ear infections in human patients having an open tympanic membrane.
17 Citations
10 Claims
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1. A method of treating a middle ear infection in a human patient comprising the steps of:
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(a) diagnosing the patient as having otitis media and an open tympanic membrane in at least one ear; and (b) topically applying into the ear canal of the patient'"'"'s ear an aqueous suspension composition containing a combination of ciprofloxacin and dexamethasone, wherein the composition comprises a) 0.01-0.5% (wt.) dexamethasone, wherein the dexamethasone has an average particle size on a mean volume basis of less than 10 μ
M;b) 0.1-0.4% (wt.) ciprofloxacin; c) 0.1-0.9% (wt.) tonicity agent; d) 0.01-0.2% (wt.) of a nonionic surfactant; e) a buffer; and wherein the composition has a pH from about 3-5. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10)
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Specification