Low oxygen in vivo analyte sensor

  • US 9,155,496 B2
  • Filed: 02/18/2011
  • Issued: 10/13/2015
  • Est. Priority Date: 03/04/1997
  • Status: Expired due to Term
First Claim
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1. A transcutaneous glucose monitoring system comprising:

  • an in vivo portion and an ex vivo portion;

    wherein the in vivo portion comprises;

    an implantable body comprising an electrode configured to measure a glucose level in a host;

    a membrane disposed over the electrode and configured to limit transport of glucose to the electrode, wherein the membrane comprises polyurethaneurea, wherein the membrane is configured to provide the system with substantial linearity at glucose concentration of up to 400 mg/dL at an oxygen concentration of 0.45 mg/L;

    a layer comprising an enzyme configured to catalyze a reaction of glucose and oxygen from a biological fluid surrounding the membrane; and

    wherein the ex vivo portion comprises a sensor electronics unit operably connected to the electrode and configured to measure a current produced by the electrode.

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