Method and apparatus for application of a neural stimulus

• US 9,155,892 B2
• Filed: 05/11/2012
• Issued: 10/13/2015
• Est. Priority Date: 05/13/2011
• Status: Active Grant

• Current Assignee: Nicta Ipr Pty. Ltd.
• Original Assignee: Saluda Medical Pty Ltd.
• Inventors: Parker, John Louis, Laird, James Hamilton
• Primary Examiner(s): Gedeon, Brian T
• Assistant Examiner(s): TEJANI, ANKIT D
• Application Number:
  US14/117,586
• Publication Number:
  US 20140243931A1
• Time in Patent Office: 1,250 Days
• US Class Current: 1/1
• CPC Class Codes: A61N 1/0551 Spinal or peripheral nerve electrodes
• CPC Class Codes: A61N 1/36071 Pain
• CPC Class Codes: A61N 1/36139 with automatic adjustment
• CPC Class Codes: A61N 1/36175 Pulse width or duty cycle

Abstract

A method of applying a neural stimulus with an implanted electrode array involves applying a sequence of stimuli configured to yield a therapeutic effect while suppressing psychophysical side effects. The stimuli sequence is configured such that a first stimulus recruits a portion of the fiber population, and a second stimulus is delivered within the refractory period following the first stimulus and the second stimulus being configured to recruit a further portion of the fiber population. Using an electrode array and suitable relative timing of the stimuli, ascending or descending volleys of evoked responses can be selectively synchronized or desynchronized to give directional control over responses evoked.

Claims

1. A method of applying a neural stimulus with an implanted electrode array, the method comprising:

using the electrode array to apply a sequence of neural stimuli configured to yield a therapeutic effect while suppressing psychophysical side effects, the stimuli sequence configured such that a first stimulus recruits a portion of the fibre population, and a second stimulus is delivered within the refractory period following the first stimulus and the second stimulus being configured to recruit a further portion of the fibre population;

wherein the sequence of neural stimuli is applied sequentially by more than one electrode, and

wherein the timing of the respective stimuli in the sequence is controlled in order to cause spatiotemporal alignment of the respective evoked responses propagating in a first direction along the nerve fibre to thereby cause correlation and summation of evoked responses in the first direction, while causing spatiotemporal misalignment of the respective evoked responses propagating in a second direction opposite the first direction along the nerve fibre, to thereby decorrelate evoked responses propagating in the second direction.

2. The method of claim 1 wherein the first direction is caudal.

3. The method of claim 1 wherein the sequence of neural stimuli comprises stimuli of ascending amplitude.

4. The method of claim 1 wherein the sequence of neural stimuli is applied by consecutive electrodes positioned along the electrode array.