MSP nanopores and related methods

  • US 9,170,230 B2
  • Filed: 03/17/2014
  • Issued: 10/27/2015
  • Est. Priority Date: 09/22/2008
  • Status: Active Grant
First Claim
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1. A mutant Mycobacterium smegmatis porin A (MspA) monomer comprising a variant of the sequence in SEQ ID NO:

  • 1, wherein the variant has at least 95% sequence identity to SEQ ID NO;

    1, and wherein the variant comprises (i) mutations such that amino acid positions 90, 91, and 93 contain amino acids with a neutral charge and (ii) one or more mutations at the following amino acid positions;

    88, 105, 108, 118, 126, 134, 138 or 139.

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