Process for preparing fluoxastrobin
First Claim
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1. A process for preparing fluoxastrobin, comprising:
- (i) reacting benzofuran-3(2H)-one O-methyl oxime (10) with an alkyl nitrite in the presence of an acid to form (3E)-2,3-benzofuran-dione O3-methyl dioxime (11A) as a predominant isomer;
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Abstract
The disclosure includes a process for preparing fluoxastrobin which includes reacting compound (10) with an alkyl nitrite in the presence of an acid to form compound (11A); reacting compound (11A) with 2-haloethanol to form compound (12A); reacting compound (12A) with a base to form compound (13); and reacting compound (13) with compound (5) and 2-chlorophenol to produce fluoxastrobin.
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15 Claims
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1. A process for preparing fluoxastrobin, comprising:
(i) reacting benzofuran-3(2H)-one O-methyl oxime (10) with an alkyl nitrite in the presence of an acid to form (3E)-2,3-benzofuran-dione O3-methyl dioxime (11A) as a predominant isomer; - View Dependent Claims (2, 3, 4, 5, 6, 7, 8)
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9. A process for preparing fluoxastrobin, comprising:
(i) reacting a 4,6-di-halo-5-fluoro-pyrimidine (5), wherein X1 is halogen, with (Z)-(5,6-dihydro-1,4,2-dioxazin-3-yl)(2-hydroxyphenyl)methanone O-methyl oxime (15), optionally in the presence of a solvent and optionally in the presence of a base, to form a (Z)-(2-((6-halo-5-fluoropyrimidin-4-yl)oxy)phenyl)(5,6-dihydro-1,4,2-dioxazin-3-yl)methanone O-methyl oxime (16);
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10. A process for preparing fluoxastrobin, comprising:
(i) reacting a 4,6-di-halo-5-fluoro-pyrimidine (5), wherein X1 is halogen, with 2-chlorophenol, optionally in the presence of a solvent and optionally in the presence of a base, to form a 4-halo-6-(2-chlorophenoxy)-5-fluoropyrimidine (17); - View Dependent Claims (11, 12, 13, 14, 15)
Specification