Photodynamic-based cardiac ablation device and method via the esophagus

• US 9,198,726 B2
• Filed: 12/31/2007
• Issued: 12/01/2015
• Est. Priority Date: 12/31/2007
• Status: Active Grant

• Current Assignee: St. Jude Medical (Abbott Laboratories Incorporated)
• Original Assignee: St. Jude Medical (Abbott Laboratories Incorporated)
• Inventors: Paul, Saurav, Byrd, Israel A.
• Primary Examiner(s): FARAH, AHMED M
• Application Number:
  US11/967,350
• Publication Number:
  US 20090171337A1
• Time in Patent Office: 2,892 Days
• Field of Search: 606 2- 19, 128/898, 607/88, 607/89, 607/92
• US Class Current: 1/1
• CPC Class Codes: A61B 18/24 with a catheter A61B18/26, A61B18/28 take precedence
• CPC Class Codes: A61B 2018/2272 with reflective or refractive surfaces for deflecting the beam A61B2018/2261, A61B2018/2266 take precedence
• CPC Class Codes: A61N 5/0601 Apparatus for use inside the body
• CPC Class Codes: A61N 5/062 Photodynamic therapy, i.e. excitation of an agent

Abstract

A method and system for ablation of cardiac tissue in a living being via the esophagus is provided. The method includes the step of introducing a photodynamic substance to the cardiac tissue. A deformable, elongated body defining a proximal end and a distal end is inserted into an esophagus of the living being. The distal end of the elongated body is located proximate the cardiac tissue. A first set of electromagnetic radiation is then directed from the distal end of the elongated body towards the cardiac tissue. Reflective and opaque surfaces at the distal end of the elongated body may be used to direct the electromagnetic radiation and an expandable membrane at the distal end may be used to urge the distal end of the elongated body to a predetermined position within the esophagus.

Claims

1. A system for ablation of cardiac tissue in a living being, the system comprising the following:

a deformable, elongated body defining a proximal end and a distal end, said elongated body configured to be received within an esophagus of said living being;

a first electromagnetic radiation source;

an electronic control unit configured to selectively activate said first electromagnetic radiation source to direct a first set of electromagnetic radiation from said distal end of said elongated body to said cardiac tissue, said tissue containing a photodynamic substance;

an electromagnetic radiation sensor external to and remote from said elongated body and configured to collect a second set of electromagnetic radiation originating from said cardiac tissue in response to said first set of electromagnetic radiation; and

an optic fiber configured to be disposed on a side of said cardiac tissue opposite said distal end of said elongated body, wherein the optic fiber is in communication with said electromagnetic radiation sensor.

2. The system of claim 1, further comprising:

a deformable membrane coupled to said elongated body proximate said distal end, said membrane covering a port in a wall of said elongated body and defining an expandable space between an interior surface of said membrane and an exterior surface of said elongated body;

wherein said distal end of said elongated body includes an opening in a lateral wall of said elongated body, said first set of electromagnetic radiation exiting through said opening and said membrane is diametrically opposite said opening.

3. The system of claim 2, wherein said electromagnetic radiation source is located at said distal end of said elongated body.

4. The system of claim 2, further comprising an optic fiber disposed within said elongated body, said electromagnetic radiation source located proximate said proximal end of said elongated body and configured to direct said first set of electromagnetic radiation through said optic fiber.

5. The system of claim 1 wherein said distal end of said elongated body includes a reflective surface configured to direct said first set of electromagnetic radiation.

6. The system of claim 5, wherein said reflective surface comprises a mirror.

7. The system of claim 1, wherein said distal end of said elongated body further includes an opaque surface that inhibits passage of said first set of electromagnetic radiation in a first direction.

8. The system of claim 1 wherein said electromagnetic radiation source is located at said distal end of said body.

9. The system of claim 1, further comprising an optic fiber disposed within said body, said electromagnetic radiation source located proximate said proximal end of said body and configured to direct said first set of electromagnetic radiation through said optic fiber.