Treatment planning for electroporation-based therapies
First Claim
1. A treatment planning system for determining a patient-specific electroporation-based treatment protocol comprising:
- a processing module operably configured for performing the following stages;
receiving and processing information from medical images of a target structure and preparing a 3-D reconstruction model of the target structure;
performing a numerical model analysis using as inputs in the analysis the 3-D reconstruction and electrical conductivity; and
constructing one or more protocols each providing a treatment region with parameters for electroporating the target structure; and
a processor for executing the stages of the processing module.
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Accused Products
Abstract
The present invention provides systems, methods, and devices for electroporation-based therapies (EBTs). Embodiments provide patient-specific treatment protocols derived by the numerical modeling of 3D reconstructions of target tissue from images taken of the tissue, and optionally accounting for one or more of physical constraints or dynamic tissue properties. The present invention further relates to systems, methods, and devices for delivering bipolar electric pulses for irreversible electroporation exhibiting reduced or no damage to tissue typically associated with an EBT-induced excessive charge delivered to the tissue.
356 Citations
30 Claims
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1. A treatment planning system for determining a patient-specific electroporation-based treatment protocol comprising:
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a processing module operably configured for performing the following stages; receiving and processing information from medical images of a target structure and preparing a 3-D reconstruction model of the target structure; performing a numerical model analysis using as inputs in the analysis the 3-D reconstruction and electrical conductivity; and constructing one or more protocols each providing a treatment region with parameters for electroporating the target structure; and a processor for executing the stages of the processing module. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17)
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18. A treatment planning method comprising:
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receiving and processing information from medical images of a target structure and preparing a 3-D reconstruction model of the target structure; performing a numerical model analysis using as inputs in the analysis the 3-D reconstruction and electrical conductivity; and constructing an electroporation protocol based on results of the analyzing; wherein the receiving, processing, analyzing, and constructing is performed in real time. - View Dependent Claims (19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30)
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Specification