Compositions and methods for modulating metabolic pathways
First Claim
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1. A method of administering a composition to a subject comprising:
- a. administering to the subject at least about 500 mg of leucine and/or at least about 200 mg of one or more metabolites thereof, wherein the one or more leucine metabolites are selected from the group consisting of keto-isocaproic acid (KIC), alpha-hydroxy-isocaproic acid, and HMB; and
b. administering to the subject an anti-diabetic agent comprising a biguanide and/or a thiazolidinedione, wherein the composition is substantially free of the individual amino acids alanine, glutamic acid, glycine, isoleucine, valine, and proline;
wherein when (a) is leucine, the molar ratio of (a) to (b) is greater than 2; and
wherein (a) and (b) are administered sequentially in any order or simultaneously.
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Abstract
Compositions and methods useful for inducing an increase in fatty acid oxidation or mitochondrial biogenesis, reducing weight gain, inducing weight loss, or increasing Sirt1, Sirt3, or AMPK activity are provided herein. Such compositions can contain synergizing amounts of a sirtuin-pathway activators, including but not limited to resveratrol, in combination with beta-hydroxymethylbutyrate (HMB), keto isocaproic acid (KIC), leucine, or combinations of HMB, KIC and leucine.
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15 Claims
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1. A method of administering a composition to a subject comprising:
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a. administering to the subject at least about 500 mg of leucine and/or at least about 200 mg of one or more metabolites thereof, wherein the one or more leucine metabolites are selected from the group consisting of keto-isocaproic acid (KIC), alpha-hydroxy-isocaproic acid, and HMB; and b. administering to the subject an anti-diabetic agent comprising a biguanide and/or a thiazolidinedione, wherein the composition is substantially free of the individual amino acids alanine, glutamic acid, glycine, isoleucine, valine, and proline; wherein when (a) is leucine, the molar ratio of (a) to (b) is greater than 2; and wherein (a) and (b) are administered sequentially in any order or simultaneously. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15)
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Specification