Method and apparatus for providing data processing and control in medical communication system

• US 9,204,827 B2
• Filed: 04/14/2008
• Issued: 12/08/2015
• Est. Priority Date: 04/14/2007
• Status: Active Grant

• Current Assignee: Abbott Diabetes Care Incorporated (Abbott Laboratories Incorporated)
• Original Assignee: Abbott Diabetes Care Incorporated (Abbott Laboratories Incorporated)
• Inventors: Hayter, Gary, Sloan, Mark K., Fennell, Martin J.
• Primary Examiner(s): PARK, HYUN D
• Application Number:
  US12/102,839
• Publication Number:
  US 20080288204A1
• Time in Patent Office: 2,794 Days
• Field of Search: 702/131, 374/100
• US Class Current: 1/1
• CPC Class Codes: A61B 5/002 Monitoring the patient using a local or closed circuit, e.g. in a room or building A61B5/0017 takes precedence
• CPC Class Codes: A61B 5/01 Measuring temperature of body parts ; Diagnostic temperature sensing, e.g. for malignant or inflamed tissue clinical contact thermometers G01K13/20
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/14546 for measuring analytes not otherwise provided for, e.g. ions, cytochromes
• CPC Class Codes: A61B 5/1473 invasive, e.g. introduced into the body by a catheter A61B5/1482 takes precedence
• CPC Class Codes: A61B 5/1486 using enzyme electrodes, e.g. with immobilised oxidase
• CPC Class Codes: A61B 5/4839 combined with drug delivery
• CPC Class Codes: A61B 5/6849 in combination with a needle set
• CPC Class Codes: A61B 5/7278 Artificial waveform generation or derivation, e.g. synthesising signals from measured signals A61B5/327 takes precedence
• CPC Class Codes: A61B 5/7435 Displaying user selection data, e.g. icons in a graphical user interface

Abstract

Methods and apparatus for providing data processing and control for use in a medical communication system are provided.

Claims

1. A method, comprising:

detecting a first temperature related signal from a first temperature sensor, the first temperature related signal corresponding to a temperature of skin within a predetermined distance of a transcutaneously positioned analyte sensor, wherein the analyte sensor includes a plurality of electrodes comprising at least one working electrode, the working electrode including an analyte-responsive enzyme and a mediator, and at least one of the analyte-responsive enzyme and the mediator is chemically bonded to a polymer disposed on the working electrode, and further wherein at least one of the analyte-responsive enzyme and the mediator is crosslinked with the polymer;

detecting a second temperature related signal from a second temperature sensor, the second temperature related signal corresponding to an ambient temperature in a housing of a data communication device, wherein the data communication device is operatively coupled to the analyte sensor and wherein the second temperature sensor is located at a predetermined distance from the first temperature sensor;

estimating an analyte temperature related signal based on the first and second detected temperature related signals; and

determining an analyte level in interstitial fluid based on the estimated analyte temperature related signal and a sensor signal from the transcutaneously positioned analyte sensor, wherein the first temperature related signal corresponding to the temperature of skin and the second temperature related signal corresponding to the ambient temperature in the housing are measured at a predetermined time of a sampling cycle of the analyte sensor;

wherein the analyte temperature related signal is estimated based on a predetermined value associated with the detected first and second temperature related signals; and

wherein the predetermined value includes a ratio of thermal resistances associated with the first and second temperature sensors.

2. The method of claim 1, wherein the predetermined time of the sampling cycle of the analyte sensor is the end of the sampling cycle of the analyte sensor.

3. The method of claim 1, further comprising determining an average temperature from a plurality of temperatures measured during the sampling cycle of the analyte sensor.

4. The method of claim 1, wherein the predetermined time of the sampling cycle of the analyte sensor is the middle of the sampling cycle of the analyte sensor.

5. The method of claim 1, further comprising detecting when the analyte sensor has been inserted into a user, and detecting when the analyte sensor has been removed from the user.

6. The method of claim 1, wherein the second temperature sensor is located within a transmitter unit housed in a sensor assembly.

7. An apparatus, comprising:

a housing;

an analyte sensor coupled to the housing and transcutaneously positionable under a skin layer of a user, wherein the analyte sensor includes a plurality of electrodes comprising at least one working electrode, the working electrode including an analyte-responsive enzyme and a mediator, and at least one of the analyte-responsive enzyme and the mediator is chemically bonded to a polymer disposed on the working electrode, and further wherein at least one of the analyte-responsive enzyme and the mediator is crosslinked with the polymer;

a first temperature detection unit coupled to the housing and configured to detect a temperature of skin within a predetermined distance of an insertion point of the analyte sensor;

a second temperature detection unit provided in the housing and configured to detect an ambient temperature within the housing; and

a processor configured to estimate an analyte temperature related signal based on the temperature of the skin and the ambient temperature within the housing, wherein the processor is further configured to receive an analyte related signal in interstitial fluid from the analyte sensor, and wherein the processor is further configured to determine an analyte value in interstitial fluid based on the estimated analyte temperature related signal and the analyte related signal in interstitial fluid;

wherein the analyte temperature related signal is estimated based on a predetermined value associated with the detected temperature of the skin and the ambient temperature within the housing; and

wherein the predetermined value includes a ratio of thermal resistances associated with the temperature of the skin and the ambient temperature within the housing.

8. The apparatus of claim 7, wherein one or more of the first temperature detection unit or the second temperature detection unit includes one or more of a thermistor, a semiconductor temperature sensor, or a resistance temperature detector (RTD).

9. The apparatus of claim 7, wherein the predetermined value is variable based on an error feedback signal associated with a monitored analyte level by the analyte sensor.

10. The apparatus of claim 9, wherein the error feedback signal is associated with a difference between a blood glucose reference value and an analyte related signal from the analyte sensor.

11. The apparatus of claim 7, further including a data communication device configured to communicate one or more signals associated with the detected temperature of the skin, the detected ambient temperature within the housing, the analyte related signal from the analyte sensor, the analyte temperature related signal based on the temperature of the skin and the ambient temperature within the housing, or a glucose value based on the estimated analyte temperature related signal and the analyte related signal from the analyte sensor.

12. The apparatus of claim 11, wherein the data communication device is an RF transmitter.

13. The apparatus of claim 7, wherein the first temperature detection unit detects the temperature of skin at a predetermined time of a sampling cycle of the analyte sensor.

14. The apparatus of claim 7, wherein the second temperature detection unit is provided in a transmitter unit within the housing.

15. A system, comprising:

a data receiver configured to receive a first temperature related signal from a first temperature sensor, the first temperature related signal corresponding to a temperature of skin within a predetermined distance of a transcutaneously positioned analyte sensor, a second temperature related signal from a second temperature sensor, the second temperature related signal corresponding to an ambient temperature in a housing of a data communication device, wherein the data communication device is operatively coupled to the analyte sensor and wherein the second temperature sensor is located at a predetermined distance from the first temperature sensor; and

a processor operatively coupled to the data receiver, and configured to estimate an analyte temperature related signal based on the first and second detected temperature signals, wherein the processor is further configured to receive an analyte related signal in interstitial fluid from the analyte sensor, and wherein the processor is further configured to determine an analyte value in interstitial fluid based on the estimated analyte temperature related signal and the analyte related signal in interstitial fluid;

wherein the analyte temperature related signal is estimated based on a predetermined value associated with the detected temperature of the skin and the ambient temperature in the housing;

wherein the predetermined value includes a ratio of thermal resistances associated with the temperature of the skin and the ambient temperature in the housing; and

wherein the analyte sensor includes a plurality of electrodes comprising at least one working electrode, the working electrode including an analyte-responsive enzyme and a mediator, and at least one of the analyte-responsive enzyme and the mediator is chemically bonded to a polymer disposed on the working electrode, and further wherein at least one of the analyte-responsive enzyme and the mediator is crosslinked with the polymer.

16. The system of claim 15, wherein the second temperature sensor is located within a transmitter unit housed in a sensor assembly.