Methods and systems for dosing a medicament

• US 9,211,378 B2
• Filed: 10/22/2010
• Issued: 12/15/2015
• Est. Priority Date: 10/22/2010
• Status: Active Grant

• Current Assignee: CeQur SA
• Original Assignee: CeQur SA
• Inventors: Boit, Christopher S., Gravesen, Peter, Arndt, Heiko, Peatfield, Gregory H., McDermott, Patrick F.
• Primary Examiner(s): Bosworth, Kami A
• Application Number:
  US12/910,437
• Publication Number:
  US 20120101451A1
• Time in Patent Office: 1,880 Days
• Field of Search: 604 82- 92, 604/183, 604/186, 604/218, 604/224, 604/246, 604/247, 604/890.1, 417/374, 417/490
• US Class Current: 1/1
• CPC Class Codes: A61M 2005/3123 having air entrapping or venting means, e.g. purging channels in pistons
• CPC Class Codes: A61M 2039/224 of the slide-valve type
• CPC Class Codes: A61M 2205/3331 Pressure; Flow
• CPC Class Codes: A61M 2205/581 by audible feedback
• CPC Class Codes: A61M 2205/582 by tactile feedback
• CPC Class Codes: A61M 2205/583 by visual feedback
• CPC Class Codes: A61M 39/223 Multiway valves
• CPC Class Codes: A61M 5/141 with capillaries for restricting fluid flow
• CPC Class Codes: A61M 5/1413 Modular systems comprising interconnecting elements
• CPC Class Codes: A61M 5/1424 Manually operated pumps
• CPC Class Codes: A61M 5/14248 of the skin patch type
• CPC Class Codes: A61M 5/148 flexible, e.g. independent bagsA61M5/155 takes precedence
• CPC Class Codes: A61M 5/16809 by repeated filling and emptying of an intermediate volume pressure infusion using positive displacement pumps A61M5/142
• CPC Class Codes: A61M 5/3153 by single stroke limiting means
• CPC Class Codes: A61M 5/3157 Means providing feedback signals when administration is completed A61M5/20 takes precedence

Abstract

A manually actuated pump, such as a bolus delivery circuit of an insulin pump, combines a direct drive piston system with a lost motion valve system, to deliver reliably a full bolus dose, while precluding partial dosing or inadvertent overdosing conditions. The pump may also include a signaling device to indicate when a full bolus dose is delivered.

Claims

1. A mechanical pump system comprising:

an actuation element;

a direct drive piston system comprising;

a piston chamber;

a piston disposed within the piston chamber;

a direct drive coupled to the actuation element for moving the piston relative to the piston chamber when the actuation element moves from a rest position to a fill end position to fill incrementally the piston chamber with medicament; and

a piston spring directly coupled to the piston for constantly biasing the piston to empty the piston chamber; and

a lost motion valve system comprising;

a valve chamber; and

a valve disposed within the valve chamber, wherein the valve is displaced from a fill position to a dosing position by contact with the actuation element after the actuation element travels beyond the fill end position.

2. The mechanical pump system of claim 1, wherein the actuation element comprises a manually operable button.

3. The mechanical pump system of claim 1, wherein the direct drive comprises at least one of a rack and gear system and a cam and follower system.

4. The mechanical pump system of claim 3, wherein the direct drive comprises both the rack and gear system and the cam and follower system.

5. The mechanical pump system of claim 4, wherein the cam and follower system comprises a cam disk with a track for constraining motion of a piston bar coupled to the piston.

6. The mechanical pump system of claim 5, wherein the track comprises a point corresponding to a point of no return of the actuation element beyond which the piston becomes decoupled from the actuation element.

7. The mechanical pump system of claim 6, wherein the direct drive further comprises a ratchet element mating with the cam disk to decouple the actuation element from the piston.

8. The mechanical pump system of claim 7, wherein the cam disk comprises a ledge for mating with the ratchet element to recouple the actuation element to the piston at a reengagement position.

9. The mechanical pump system of claim 8, wherein the ratchet element and the cam disk are configured such that cycling of the actuation element from past the point of no return to a position intermediate with the reengagement position fails to deliver medicament through the valve.

10. The mechanical pump system of claim 1, wherein the actuation element forms a gap with the valve, such that the valve does not move when the actuation element moves from the rest position to the fill end position.

11. The mechanical pump of claim 1 further comprising a return spring for biasing the actuation element toward the rest position.

12. The mechanical pump of claim 1, wherein the valve fluidically couples a reservoir and the piston chamber only when the valve is in the fill position.

13. The mechanical pump system of claim 1, wherein the valve fluidically couples the piston chamber and a dosing conduit only when the valve is in the dosing position.

14. The mechanical pump system of claim 1, wherein the valve system is configured to preclude direct fluidic communication between a reservoir and a dosing conduit.

15. The mechanical pump system of claim 1, wherein the valve system further comprises at least one fluidic outlet for dumping medicament if pressure exceeds a predetermined limit.

16. The mechanical pump system of claim 1, wherein the piston chamber contains a full dose of medicament when the actuation element is at the fill end position, thereby precluding delivery of a partial dose of medicament to a dosing conduit.

17. The mechanical pump system of claim 1, wherein moving the actuation element from the rest position to the fill end position compresses the piston spring and an actuation element return spring, resulting in a first increasing reaction force, and moving the actuation element past the fill end position toward the point of no return compresses further solely the return spring.

18. The mechanical pump system of claim 1 further comprising a signaling device for delivering a signal as a full dose of medicament is delivered.

19. A mechanical pump system comprising:

an actuation element;

a direct drive piston system comprising;

a piston chamber;

a piston disposed within the piston chamber;

a direct drive coupled to the actuation element for moving the piston relative to the piston chamber when the actuation element moves from a rest position to a fill end position to fill incrementally the piston chamber with medicament, wherein the direct drive comprises at least one of a rack and gear system and a cam and follower system; and

a piston spring directly coupled to the piston for constantly biasing the piston to empty the piston chamber; and

a lost motion valve system comprising;

a valve chamber; and

a valve disposed within the valve chamber,

wherein the valve is displaced from a fill position to a dosing position after the actuation element travels beyond the fill end position.

20. The mechanical pump system of claim 19, wherein the direct drive comprises both the rack and gear system and the cam and follower system.

21. The mechanical pump system of claim 20, wherein the cam and follower system comprises a cam disk with a track for constraining motion of a piston bar coupled to the piston.

22. The mechanical pump system of claim 21, wherein the track comprises a point corresponding to a point of no return of the actuation element beyond which the piston becomes decoupled from the actuation element.

23. The mechanical pump system of claim 22, wherein the direct drive further comprises a ratchet element mating with the cam disk to decouple the actuation element from the piston.

24. The mechanical pump system of claim 23, wherein the cam disk comprises a ledge for mating with the ratchet element to recouple the actuation element to the piston at a reengagement position.

25. The mechanical pump system of claim 24, wherein the ratchet element and the cam disk are configured such that cycling of the actuation element from past the point of no return to a position intermediate with the reengagement position fails to deliver medicament through the valve.