Implantable or insertable medical devices
First Claim
1. An implantable or insertable medical device comprising (a) a silicone-containing region that comprises silicone, (b) a polymeric layer comprising a block copolymer and a therapeutic agent disposed over the silicone-containing region, said block copolymer comprising at least one high Tg polymer block comprising at least one first monomer and at least one low Tg polymer block comprising polyisobutylene, and (c) a tie layer between the silicone-containing region and the polymeric layer, said tie layer comprising an additional polymer, wherein the block copolymer and the additional polymer are different from one another, wherein the additional polymer is grafted to the surface of the silicone-containing region, and wherein the additional polymer comprises a monomer selected from styrene, isobutylene, and a combination of styrene and isobutylene.
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Accused Products
Abstract
In various aspects, the present invention is directed to implantable neurostimulation leads and methods for their formation. In various additional aspects, the present invention is directed to medical devices having silicone-containing regions with overlying polymeric layers and to methods of forming the same.
81 Citations
25 Claims
- 1. An implantable or insertable medical device comprising (a) a silicone-containing region that comprises silicone, (b) a polymeric layer comprising a block copolymer and a therapeutic agent disposed over the silicone-containing region, said block copolymer comprising at least one high Tg polymer block comprising at least one first monomer and at least one low Tg polymer block comprising polyisobutylene, and (c) a tie layer between the silicone-containing region and the polymeric layer, said tie layer comprising an additional polymer, wherein the block copolymer and the additional polymer are different from one another, wherein the additional polymer is grafted to the surface of the silicone-containing region, and wherein the additional polymer comprises a monomer selected from styrene, isobutylene, and a combination of styrene and isobutylene.
Specification