Apparatus for extracorporeal blood treatment

• US 9,220,827 B2
• Filed: 08/17/2011
• Issued: 12/29/2015
• Est. Priority Date: 08/17/2010
• Status: Active Grant

• Current Assignee: B. Braun Avitum AG (B. Braun Holding GmbH & Co. KG)
• Original Assignee: B. Braun Avitum AG (B. Braun Holding GmbH & Co. KG)
• Inventors: Meibaum, Joern, Moll, Stefan, Castellarnau, Alex
• Primary Examiner(s): Wiest, Philip R
• Assistant Examiner(s): Zimbouski, Ariana
• Application Number:
  US13/816,968
• Publication Number:
  US 20130237896A1
• Time in Patent Office: 1,595 Days
• US Class Current: 1/1
• CPC Class Codes: A61M 1/14 Dialysis systems; Artificial kidneys; Blood oxygenators semi-permeable membranes characterised by the material, manufacturing processes therefor B01D71/00; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
• CPC Class Codes: A61M 1/16 with membranes
• CPC Class Codes: A61M 1/1609 after use, i.e. downstream of dialyser
• CPC Class Codes: A61M 1/1613 Profiling or modelling of patient or predicted treatment evolution or outcome
• CPC Class Codes: A61M 1/361 before treatment
• CPC Class Codes: A61M 1/3612 after treatment
• CPC Class Codes: A61M 2202/0498 Urea
• CPC Class Codes: A61M 2205/3306 Optical measuring means
• CPC Class Codes: A61M 2205/3313 used specific wavelengths
• CPC Class Codes: A61M 2205/52 with memories providing a history of measured variating parameters of apparatus or patient
• CPC Class Codes: G01N 21/33 using ultraviolet light G01N21/39 takes precedence

Abstract

The invention describes an apparatus for extracorporeal blood treatment with a dialyzer which is separated by a semipermeable membrane in to a first and second chamber (29, 30), wherein the first chamber (29) is arrange in a dialysate pathway and the second chamber (30) is connectable to the blood circulation of a patient by means of a blood supply conduit (32) and a blood return conduit (31), an inlet (20) for fresh dialysate, an outlet (30) for spent dialysate, a measuring device (37) arranged in the outlet (36), wherein said measuring device (37) has at least one radiation source consisting of several light sources (1) for electromagnetic radiation. The invention is characterized in that the measuring device (37) is designed to generate substantially monochromatic electromagnetic radiation of different wavelengths, and to lead only one of these wavelength (at the same time) though the outlet (36) for spent dialysate, wherein at least one detector system (5) is provided for detection of the intensity or the absorption of the substantially monochromatic electromagnetic radiation passing through the outlet (36) for spent dialysate.

Claims

1. Apparatus for extracorporeal blood treatment with:

a dialyzer which is separated by a semipermeable membrane into a first and second chamber, wherein the first chamber is arranged in a dialysate pathway and the second chamber is connectable to the blood circulation of a patient by means of a blood supply conduit and a blood return conduit,

an inlet for fresh dialysate,

an outlet for spent dialysate,

a measuring device arranged in the outlet, wherein the measuring device has a radiation source for electromagnetic UV radiation,

wherein the radiation source comprises either at least two monochromatic light sources or at least one polychromatic light source with monochromators for generating monochromatic UV radiation,

a microprocessor unit, a storage unit as well as an output unit, wherein the measuring device is designed to generate substantially monochromatic electromagnetic UV-radiation of different wavelengths and to lead it through the outlet for spent dialysate, wherein at least one detector system is provided for the detection of the intensity or the absorption of the substantially monochromatic electromagnetic UV-radiation passing through the outlet for spent dialysate and in the storage unit a first equation system

2. Apparatus according to claim 1, wherein the radiation source consisting of several light sources is designed for the emission of electromagnetic radiation in the range of 180 nm to 380 nm.

3. Apparatus according to claim 1, wherein the radiation source has a plurality of light emitting diodes which are designed in each case for generating a substantially monochromatic electromagnetic UV radiation.

4. Apparatus according to claim 1, wherein the radiation source is designed for generating polychromatic electromagnetic radiation and for generating the substantially monochromatic electromagnetic radiation corresponding monochromators, including at least one of an optical filter which allows passage of only a specific wavelength or a band-pass filter with several pass ranges are provided.

5. Apparatus according to claim 1, wherein the microprocessor unit is designed to solve the equation system

6. Apparatus according to claim 5, wherein the reference substance is selected from the group comprising the UV active uremic toxins creatinine, uric acid, hippuric acid, indoxyl sulfate, 4-hydroxynonenal, malondialdehyde, p-cresol, phenol, retinol-binding protein and β

2microglobulin-fragments or combinations thereof.

7. Apparatus according to claim 1, wherein the reference substance is selected from the group comprising the UV active uremic toxins creatinine, uric acid, hippuric acid, indoxyl sulfate, 4-hydroxynonenal, malondialdehyde, p-cresol, phenol, retinol-binding protein and β

2-microglobulin-fragments or combinations thereof.

8. Apparatus according to claim 6, wherein as reference substance uric acid is used.

9. Apparatus according to claim 1, wherein as reference substance uric acid is used.

10. Apparatus according to claim 5, wherein the reference wavelength λ

₁ is in the range between 280 nm and 300 nm.

11. Apparatus according to claim 1, wherein the reference wavelength λ

₁ is in the range between 280 nm and 300 nm.

12. Apparatus according to claim 1, wherein the radiation source is 10 monochromatic light sources.

13. Apparatus according to claim 1, wherein the detection of the intensity or the absorption is carried out at the wavelengths λ

=320 nm, λ

=310 nm, λ

=305 nm, λ

=300 nm, λ

=290 nm, λ

=280 nm, λ

=270 nm, λ

=266 nm, λ

=260 nm, λ

=250 nm, λ

=245 nm, λ

=240 nm, λ

=235 nm, λ

=230 nm, λ

=220 nm and λ

=205 nm.