Tracking and controlling fluid delivery from chamber

• US 9,222,819 B2
• Filed: 06/01/2012
• Issued: 12/29/2015
• Est. Priority Date: 02/20/2009
• Status: Active Grant

• Current Assignee: University of Southern California
• Original Assignee: University of Southern California
• Inventors: Gutierrez, Christian A., Meng, Ellis
• Primary Examiner(s): Caputo, Lisa
• Assistant Examiner(s): ROY, PUNAM P
• Application Number:
  US13/487,000
• Publication Number:
  US 20120234859A1
• Time in Patent Office: 1,306 Days
• US Class Current: 1/1
• CPC Class Codes: B67D 1/0437 comprising a gas pressure space within the container for the liquid
• CPC Class Codes: B67D 1/0855 concerning the used flowmeter flowmeter per se G01F1/00, G01F3/00
• CPC Class Codes: G01F 11/086 using an auxiliary pressure to cooperate with the diaphragm or bellows
• CPC Class Codes: G01F 3/20 having flexible movable walls, e.g. diaphragms, bellows
• CPC Class Codes: G01F 3/227 characterised by the means for transfer of membrane movement information to indicating means
• CPC Class Codes: G01M 3/16 using electric detection means G01M3/045, G01M3/06, G01M3/12, G01M3/20, G01M3/24, G01M3/26 take precedence
• CPC Class Codes: G01M 3/40 by using electric means, e.g. by observing electric discharges

Abstract

Electrochemical impedance may be used for accurate and real-time tracking and control of fluid delivery from fluid-filled chambers, such as from drug delivery devices. At least two measurement electrodes may be placed within the chamber in contact with the fluid to be sensed. Application of a small alternating current using these electrodes through the fluid/drug may allow measurement of electrochemical impedance. Volumetric changes of the compressible chamber due to movement of at least one surface within the compressible chamber (such as an actuating bellows or flexible diaphragm), may induce changes in the measured electrochemical impedance. Measuring these changes may allow for tracking of ejected liquid volumes from the compressible chamber. By taking the time-derivative of this signal, the rate of volume change can be tracked and therefore the rate of ejected fluid (flow rate) can be deduced.

Claims

1. A fluid dosing device for delivering one or more doses of fluid comprising:

a chamber configured to contain fluid;

a chamber compressor configured to controllably apply pressure to fluid within the chamber;

an outlet from the chamber configured to allow fluid to escape from the chamber when pressure is applied to the fluid; and

an impedance detection system configured to detect changes in the electrochemical impedance of fluid within the chamber caused by changes in the volume of the fluid caused by fluid escaping the chamber,

wherein one or both of the following;

the impedance detection system includes at least two physically-separated electrodes that do not move in response to fluid escaping the chamber;

or

the impedance detection system detects an increase in the electrochemical impedance of the fluid in response to fluid escaping the chamber.

2. The fluid dosing device of claim 1 wherein the impedance detection system includes at least two physically-separated electrodes configured to be in contact with fluid in the chamber and an impedance measurement system configured to measure the electrochemical impedance between the electrodes.

3. The fluid dosing device of claim 2 wherein the impedance measurement system is configured to output information indicative of the volume of fluid delivered through the outlet based on changes in the electrochemical impedance between the electrodes, as measured by the impedance measurement system.

4. The fluid dosing device of claim 3 further comprising a controller configured to cause the chamber compressor to apply pressure to fluid within the chamber in a manner that causes a single dose of fluid that escapes through the outlet to have a specified volume based on feedback to the controller from the impedance measurement system of the information indicative of the volume of fluid that is delivered through the outlet.

5. The fluid dosing device of claim 4 wherein the chamber, outlet, chamber compressor, and impedance detection system are configured to collectively permit the specified volume to be less than 100 mL.

6. The fluid dosing device of claim 5 wherein the chamber, outlet, chamber compressor, and impedance detection system are configured to collectively permit the specified volume to be greater than 1 nL.

7. The fluid dosing device of claim 2 wherein the impedance measurement system is configured to output information indicative of the rate at which fluid is delivered through the outlet based on the rate of change in the electrochemical impedance between the electrodes, as measured by the impedance measurement system.

8. The fluid dosing device of claim 7 further comprising a controller configured to cause the chamber compressor to apply pressure to fluid within the chamber in a manner that causes fluid to escape through the outlet at a specified rate based on feedback to the controller from the impedance measurement system of the information indicative of the rate of change in the electrochemical impedance between the electrodes.

9. The fluid dosing device of claim 8 wherein the chamber, outlet, chamber compressor, and impedance detection system are configured to collectively permit the specified rate to be less than 1 μ

L/min.

10. The fluid dosing device of claim 8 wherein the chamber, outlet, chamber compressor, and impedance detection system are configured to collectively permit the specified rate to be greater than 100 μ

L/min.

11. The fluid dosing device of claim 2 further comprising a blockage detector configured to output information indicative of a blockage in the outlet based on the absence of changes in the electrochemical impedance between the electrodes, as measured by the impedance measurement system, while the chamber compressor is controllably applying pressure to fluid within the chamber.

12. The fluid dosing device of claim 2 further comprising a leakage detector configured to output information indicative of leakage through the outlet based on changes in the electrochemical impedance between the electrodes, as measured by the impedance measurement system, in the absence of efforts by the chamber compressor to controllably apply pressure to fluid within the chamber.

13. The fluid dosing device of claim 2 further comprising a leakage detector configured to output information indicative of leakage from the chamber compressor to the compressible chamber based on changes in the electrochemical impedance between the electrodes, as measured by the impedance measurement system, in the absence of efforts by the chamber compressor to controllably apply pressure to fluid within the chamber.

14. The fluid dosing device of claim 2 wherein the impedance measurement system is configured to deliver an AC signal to the electrodes.

15. The fluid dosing device of claim 14 wherein the AC signal has a frequency of between 1 kHz and 50 kHz.

16. The fluid dosing device of claim 14 wherein the AC signal has an amplitude that does not cause any appreciable amount of irreversible chemical reaction in the fluid.

17. The fluid dosing device of claim 16 wherein the AC signal has a peak-to-peak amplitude of between 10 millivolts and 1 volt.

18. The fluid dosing device of claim 2 wherein the chamber, chamber compressor, outlet, and electrodes are configured to be implanted within a living organism.

19. The fluid dosing device of claim 18 wherein the second chamber is configured to contain a fluid and further comprising electrodes within the second chamber configured to be in contact with the fluid and to cause the fluid to undergo electrolysis when electricity passes through the electrodes.

20. The fluid dosing device of claim 1 wherein the chamber is a first chamber and wherein the chamber compressor includes a second chamber within the first chamber that is configured to controllably expand.

21. The fluid dosing device of claim 1 further comprising an inlet to the chamber configured to allow the chamber to be filed with fluid and wherein the impedance detection system is configured to detect changes in the electrochemical impedance of fluid within the chamber while fluid enters the chamber.

22. The fluid dosing device of claim 1 wherein the chamber is compressible and wherein the chamber compressor is configured to controllably compress the chamber.

23. The fluid dosing device of claim 1 wherein the impedance detection system detects an increase in the electrochemical impedance of the fluid in response to fluid escaping the chamber.

24. The fluid dosing device of claim 1 wherein the impedance detection system includes at least two physically-separated electrodes that do not move in response to fluid escaping the chamber.