Magnetic stimulation devices and methods of therapy

• US 9,233,258 B2
• Filed: 03/03/2015
• Issued: 01/12/2016
• Est. Priority Date: 11/10/2005
• Status: Expired due to Fees

• Current Assignee: Electrocore, Llc
• Original Assignee: Electrocore, Llc
• Inventors: Simon, Bruce J., Errico, Joseph P., Raffle, Jonn T.
• Primary Examiner(s): Gedeon, Brian T
• Assistant Examiner(s): TEJANI, ANKIT D
• Application Number:
  US14/636,498
• Publication Number:
  US 20150165226A1
• Time in Patent Office: 315 Days
• Field of Search: None
• US Class Current: 1/1
• CPC Class Codes: A61N 1/36114 Cardiac control, e.g. by vagal stimulation stimulating the heart A61N1/362
• CPC Class Codes: A61N 1/40 Applying electric fields by inductive or capacitive coupling microwave apparatus A61N5/00; Applying radio-frequency signals
• CPC Class Codes: A61N 2/006 for magnetic stimulation of nerve tissue
• CPC Class Codes: A61N 2/02 using magnetic fields produced by coils, including single turn loops or electromagnets A61N2/12 takes precedence

Abstract

Devices and systems are disclosed for the non-invasive treatment of medical conditions through delivery of energy to target tissue, comprising a source of electrical power, a magnetically permeable toroidal core, and a coil that is wound around the core. The coil and core are embedded in a continuous electrically conducting medium, which is adapted to have a shape that conforms to the contour of an arbitrarily oriented target body surface of a patient. The conducting medium is applied to that surface by any of several disclosed methods, and the source of power supplies a pulse of electric charge to the coil, such that the coil induces an electric current and/or an electric field within the patient, thereby stimulating tissue and/or one or more nerve fibers within the patient. The invention shapes an elongated electric field of effect that can be oriented parallel to a long nerve. In one embodiment, the device comprises two toroidal cores that lie adjacent to one another.

Claims

1. A device for selectively applying energy to a target region in a patient, the device comprising:

a power source configured to generate a magnetic field outside of the patient;

a housing containing an enclosed coil and an electrically conductive fluid surrounding at least a portion of the enclosed coil; and

wherein the enclosed coil is configured to transmit the magnetic field through an outer skin surface of the patient such that the magnetic field induces an electric current at a nerve at the target region within the patient, wherein the electric current comprises bursts of electrical impulses, wherein each of the electrical impulses comprises a duration from about 50 microseconds to about 1000 microseconds, wherein each of the bursts comprises a frequency from about 15 Hz to about 50 Hz, wherein the electric current is sufficient to modulate the nerve.

2. The device of claim 1, wherein the target region is a nerve at least 1 cm below the outer skin surface.

3. The device of claim 1, wherein the target region is a nerve at least 2 cm below the outer skin surface.

4. The device of claim 1, further comprising:

a second enclosed coil positioned adjacent to or near the enclosed coil, and wherein the power source is configured to generate a second magnetic field within the second enclosed coil.

5. The device of claim 1, further comprising:

an electrical insulator positioned around a portion of the enclosed coil such that a component of the electric current normal to a surface of the insulator is zero.

6. The device of claim 1, wherein the enclosed coil is configured to induce an electric field at the target region, wherein the electric field allows the electric current to flow through the outer skin surface of the patient.

7. The device of claim 1, wherein each of the electrical impulses comprises a duration from about 50 microseconds to about 400 microseconds.

8. The device of claim 1, wherein the nerve is a vagus nerve.

9. The device of claim 1, further comprising:

an electrically conductive contact surface coupled to the enclosed coil, wherein the electrically conductive contact surface is configured to transmit the magnetic field through a skin surface of a neck of the patient to a vagus nerve of the patient.

10. The device of claim 1, wherein the housing comprises a handheld device with an interior, and wherein the enclosed coil is substantially surrounded by the electrically conductive fluid within the interior.

11. The device of claim 1, wherein the electrically conductive fluid comprises an electrically conductive gel.

12. The device of claim 1, wherein the electrically conductive fluid comprises an electrically conductive liquid.

13. A method comprising:

applying an energy selectively to a target region within a patient, wherein the applying is via a device comprising a power source and a housing, wherein the power source generates a magnetic field outside of the patient, wherein the housing contains an enclosed coil and an electrically conductive fluid surrounding at least a portion of the enclosed coil, wherein the enclosed coil transmits the magnetic field through an outer skin surface of the patient such that the magnetic field induces an electric current at a nerve at the target region within the patient, wherein the electric current comprises bursts of electrical impulses, wherein each of the electrical impulses comprises a duration from about 50 microseconds to about 1000 microseconds, wherein each of the bursts comprises a frequency from about 15 Hz to about 50 Hz, wherein the electric current is sufficient to modulate the nerve.