Methods of treating acne
DC CAFC
First Claim
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1. A method for treating acne in a human in need thereof, the method comprisingadministering orally to said human doxycycline, or a pharmaceutically acceptable salt thereof,in an amount that(i) is effective to treat acne;
- (ii) is 10-80% of a 50 mg dose of doxycycline per day; and
(iii) results in no reduction of skin microflora during a six-month treatment, without administering a bisphosphonate compound,wherein said doxycycline, or a pharmaceutically acceptable salt thereof, is administered in an amount which provides a serum concentration in the range of about 0.1 to about 0.8 μ
g/ml.
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Abstract
A method of treating acne in a human in need thereof comprising administering systemically to said human a tetracycline compound in an amount that is effective to treat acne but has substantially no antibiotic activity, without administering a bisphosphonate compound.
9 Citations
32 Claims
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1. A method for treating acne in a human in need thereof, the method comprising
administering orally to said human doxycycline, or a pharmaceutically acceptable salt thereof, in an amount that (i) is effective to treat acne; -
(ii) is 10-80% of a 50 mg dose of doxycycline per day; and (iii) results in no reduction of skin microflora during a six-month treatment, without administering a bisphosphonate compound, wherein said doxycycline, or a pharmaceutically acceptable salt thereof, is administered in an amount which provides a serum concentration in the range of about 0.1 to about 0.8 μ
g/ml. - View Dependent Claims (2, 3, 4, 5, 6, 18, 19, 20, 21, 22)
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7. A method for treating acne in a human in need thereof, the method comprising
administering orally to said human doxycycline, or a pharmaceutically acceptable salt thereof, in an amount that (i) is effective to treat acne; -
(ii) is 40-80% of a 50 mg dose of doxycycline per day; and (iii) results in no reduction of skin microflora during a six-month treatment, without administering a bisphosphonate compound, wherein said doxycycline, or a pharmaceutically acceptable salt thereof, is administered in an amount which provides a serum concentration in the range of about 0.1 to about 0.8 μ
g/ml. - View Dependent Claims (8, 9, 10, 11, 12, 23, 24, 25, 26, 27)
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13. A method for treating acne in a human in need thereof, the method comprising
administering orally to said human doxycycline, or a pharmaceutically acceptable salt thereof, in an amount of 40 mg per day, wherein the amount results in no reduction of skin microflora during a six-month treatment, without administering a bisphosphonate compound, wherein said doxycycline, or a pharmaceutically acceptable salt thereof, is administered in an amount which provides a serum concentration in the range of about 0.1 to about 0.8 μ
Specification
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Litigation Data
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Current AssigneeGalderma Laboratories Incorporated (Nestle SA)
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Original AssigneeGalderma Laboratories Incorporated (Nestle SA)
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InventorsAshley, Robert A.
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Primary Examiner(s)TRAN, SUSAN T
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Application NumberUS14/753,544Publication NumberTime in Patent Office211 DaysField of SearchNoneUS Class Current1/1CPC Class CodesA61K 31/135 having aromatic rings , e.g...A61K 31/65 TetracyclinesA61K 9/0053 Mouth and digestive tract, ...A61P 17/10 Anti-acne agentsD06M 16/00 Biochemical treatment of fi...
