Reversing intestinal inflammation by inhibiting retinoic acid metabolism
First Claim
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1. A method of reducing chronic intestinal inflammation in an individual with familial adenomatous polyposis (FAP), the method comprising:
- administering to the individual an effective dose of an agent that increases local concentration of retinoic acid (RA) through modifying enzymatic pathways involved in RA metabolism, wherein the agent is not retinoic acid, and wherein inflammation is reduced.
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Abstract
An agent that increases local concentration of retinoic acid (RA) in the intestine through modifying enzymatic pathways involved in RA metabolism is administered in a dose effective to inhibit or reverse production of inflammatory mediators by intestinal dendritic cells and thereby reduce intestinal inflammation and tumor growth associated with intestinal inflammation.
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8 Claims
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1. A method of reducing chronic intestinal inflammation in an individual with familial adenomatous polyposis (FAP), the method comprising:
administering to the individual an effective dose of an agent that increases local concentration of retinoic acid (RA) through modifying enzymatic pathways involved in RA metabolism, wherein the agent is not retinoic acid, and wherein inflammation is reduced. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8)
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