Packaging system for oxygen-sensitive drugs

  • US 9,248,229 B2
  • Filed: 03/12/2014
  • Issued: 02/02/2016
  • Est. Priority Date: 03/14/2013
  • Status: Active Grant
First Claim
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1. A pharmaceutical packaging system for an injectable oxygen-sensitive drug, the packaging system comprising:

  • (i) a syringe filled under inert conditions with an injectable oxygen-sensitive drug, wherein the syringe has an oxygen permeable tip cap and wherein the oxygen-sensitive drug is one of morphine, hydromorphone, and promethazine;

    (ii) a hermetically sealed oxygen barrier blister packaging which houses the syringe, wherein the blister packaging comprises a multilayer bottom web comprising ethylene vinyl alcohol (EVOH) and a multilayer top web lid comprising aluminum foil or EVOH; and

    (iii) an oxygen absorber, wherein the oxygen absorber reduces the oxygen level present from the time of packaging assembly to about zero percent in about one to three days in the blister packaging and in about one to three months in the syringe.

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