Methods of producing an electrochemical sensor for determining an analyte concentration

• US 9,255,903 B2
• Filed: 08/06/2014
• Issued: 02/09/2016
• Est. Priority Date: 08/08/2006
• Status: Active Grant

• Current Assignee: Roche Diabetes Care Inc. (Roche Holding AG)
• Original Assignee: Roche Diabetes Care Inc. (Roche Holding AG)
• Inventors: Marquant, Michael, Bainczyk, Gregor
• Primary Examiner(s): Kaur, Gurpreet
• Application Number:
  US14/452,825
• Publication Number:
  US 20140345130A1
• Time in Patent Office: 552 Days
• US Class Current: 1/1
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/14865 invasive, e.g. introduced into the body by a catheter or needle or using implanted sensors
• CPC Class Codes: C25D 5/48 After-treatment of electroplated surfaces
• CPC Class Codes: G01N 27/301 Reference electrodes
• CPC Class Codes: G01N 27/327 Biochemical electrodes , e.g. electrical or mechanical details for in vitro measurements
• CPC Class Codes: G01N 27/3272 Test elements therefor, i.e. disposable laminated substrates with electrodes, reagent and channels optical biosensors G01N33/52
• CPC Class Codes: G01N 27/4166 measuring a particular property of an electrolyte
• CPC Class Codes: G01N 33/4833 of solid biological material, e.g. tissue samples, cell cultures tissue in vivo A61B5/00; cell suspensions G01N33/48735
• CPC Class Codes: H01R 43/16 for manufacturing contact members, e.g. by punching and by bending
• CPC Class Codes: Y10T 29/49204 Contact or terminal manufacturing

Abstract

The invention relates to an electrochemical sensor for the determination of a concentration of at least one analyte in a medium, in particular a body tissue and/or a body fluid, to an apparatus that includes the electrochemical sensor, and to a use of the electrochemical sensor, and finally to a method for producing it. The electrochemical sensor has an isolation element and at least two electrodes. The at least two electrodes comprise at least one working electrode and at least one further electrode, in particular at least one counter electrode and/or at least one reference electrode. The at least two electrodes run parallel to one another and form an electrochemical measuring cell of the electrochemical sensor.

Claims

1. A method of producing an electrochemical sensor for determining an analyte concentration in a body tissue or a body fluid, comprising the following steps:

providing at least two electrodes and coating at least one of the at least two electrodes with a reagent medium for detecting the analyte;

assembling a slab-shaped electrode pack by providing an isolation element having a profiled shape and having at least two holding compartments, and extending the at least two electrodes along the isolation element into respective ones of the holding compartments;

subjecting either individual ones of the at least two electrodes or the electrode pack to an immobilization medium coating operation; and

feeding the electrode pack to a cut-to-length operation for separation.

2. The method as claimed in claim 1, further comprising the step of passing the at least one of the two electrodes through a drying station after the step of coating with the reagent medium.

3. The method as claimed in claim 1, wherein one or both of the step of coating with the reagent medium and the step of subjecting to the immobilization medium coating operation are carried out by use of one of an annular nozzle coating method and an electroplating method.

4. The method as claimed in claim 3, wherein the step of coating with the reagent medium comprises use of a first annular nozzle for substantially wetting the surface of the at least one of the at least two electrodes.

5. The method as claimed in claim 3, wherein the step of subjecting to the immobilization medium coating operation comprises use of a second annular nozzle for substantially coating the individual ones of the at least two electrodes or the electrode pack with an immobilization medium.

6. The method as claimed in claim 1, wherein the cut-to-length operation comprises separating individual sections of the electrode pack into application-specific lengths.