Compositions and methods for eye whitening

  • US 9,259,425 B2
  • Filed: 10/03/2013
  • Issued: 02/16/2016
  • Est. Priority Date: 12/17/2009
  • Status: Active Grant
First Claim
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1. A method of increasing whiteness of an eye comprising administering to a subject in need thereof a composition comprising from between about 0.001% to about 0.05% weight by volume of a selective α

  • -2 adrenergic receptor agonist selected from lofexidine, apraclonidine, mivazerol, clonidine, brimonidine, alpha methyl dopa, guanfacine, dexmedetomidine, (+)-(S)-4-[1-(2,3-dimethyl-phenyl)-ethyl]-1,3-dihydro-imidazole-2-thione, and 1-[(imidazolidin-2-yl)imino]indazole, or a pharmaceutically acceptable salt thereof.

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