Retinal prosthesis

• US 9,265,945 B2
• Filed: 02/03/2010
• Issued: 02/23/2016
• Est. Priority Date: 02/09/2009
• Status: Active Grant

• Current Assignee: Nano-Retina Inc.
• Original Assignee: Nano-Retina Inc.
• Inventors: Gross, Yossi, Vaingast, Shai, Gefen, Ra'anan
• Primary Examiner(s): Kahelin, Michael
• Assistant Examiner(s): PHAM, MINH DUC GIA
• Application Number:
  US13/148,461
• Publication Number:
  US 20120041514A1
• Time in Patent Office: 2,211 Days
• Field of Search: 607/53
• US Class Current: 1/1
• CPC Class Codes: A61N 1/0543 Retinal electrodes
• CPC Class Codes: A61N 1/36046 of the eye
• CPC Class Codes: A61N 1/37217 characterised by the communication link, e.g. acoustic or tactile
• CPC Class Codes: A61N 1/3787 from an external energy source
• CPC Class Codes: H01L 27/14621 Colour filter arrangements
• CPC Class Codes: H01L 27/14627 Microlenses
• CPC Class Codes: H01L 31/145 the semiconductor device sensitive to radiation being characterised by at least one potential-jump barrier or surface barrier

Abstract

An external device (20) includes a mount (22), which is placed in front of a subject'"'"'s eye. A laser (24) is coupled to the mount (22) and emits radiation (26) that is outside of 380-750 nm. A partially-transparent mirror (23) is coupled to the mount (22). An intraocular device (30) is implanted entirely in the subject'"'"'s eye, and includes a plurality of stimulating electrodes (38), and an energy receiver (32), which receives the radiation (26) from the laser (24) and generates a voltage drop. A plurality of photosensors (34) detect photons (33) and generate a signal. Driving circuitry (36) is coupled to the energy receiver (32) and to the photosensors (34), and receives the signals from the photosensors (34) and utilizes the voltage drop to drive the electrodes (38) to apply currents to the retina in response to the signals from the photosensors (34). Other embodiments are also described.

Claims

1. Apparatus, comprising:

an external device, comprising;

a mount, configured to be placed in front of an eye of a subject; and

a power source coupled to the mount and configured to emit radiation that is outside of 380-750 nm; and

an intraocular device configured to be implanted entirely in the subject'"'"'s eye, the intraocular device comprising;

an energy receiver, configured to receive the radiation from the power source and to generate a voltage drop in response thereto;

a plurality of stimulating electrodes;

a plurality of photosensors, each photosensor configured to detect photons and to generate a signal in response thereto; and

driving circuitry, coupled to the energy receiver and to the photosensors, and configured to receive the signals from the photosensors and to utilize the voltage drop to drive the electrodes to apply currents to a retina of the eye in response to the signals from the photosensors,

wherein the external device is configured to modulate the radiation emitted from the power source using an encoding protocol such that pulses of the radiation are encoded by the encoding protocol, and

wherein the driving circuitry is configured to regulate a parameter of operation of the driving circuitry in response to the modulation of the radiation emitted from the power source, and

wherein the driving circuitry is configured to control a sensitivity of the photosensors, by the regulating of the parameter by the driving circuitry.

2. The apparatus according to claim 1, further comprising a partially-transparent mirror coupled to the mount.

3. The apparatus according to claim 1, wherein the power source comprises a laser.

4. The apparatus according to claim 1,

wherein the power source is configured to emit the radiation at 790-850 nm, and

wherein the energy receiver is configured to receive radiation at 790-850 nm and to generate the voltage drop in response thereto.

5. The apparatus according to claim 1, wherein the photosensors are generally insensitive to the radiation from the power source.

6. The apparatus according to claim 1, wherein the photosensors are generally sensitive to visible light.

7. The apparatus according to claim 1, wherein the intraocular device comprises a filter configured to allow transmission to the photosensors of visible light only.

8. The apparatus according to claim 1, wherein the intraocular device further comprises extending elements to facilitate dissipation of heat away from at least the energy receiver.

9. The apparatus according to claim 1, wherein the electrodes comprise needle electrodes having exposed tips.

10. The apparatus according to claim 1, wherein the plurality of stimulating electrodes comprises at least 100 electrodes.

11. The apparatus according to claim 1, wherein the intraocular device is configured to be implanted in an epi-retinal position.

12. The apparatus according to claim 1, further comprising a control element coupled to the mount and configured to receive an input from the subject, and wherein the external device is configured to modulate the radiation emitted from the power source in response to the input.

13. The apparatus according to claim 1, wherein the driving circuitry is configured to control an amount of stimulation per unit time applied by the electrodes, in response to the modulation of the radiation emitted from the power source.

14. The apparatus according to claim 1, wherein the driving circuitry is configured to control an amplitude of the currents applied by the electrodes, in response to the modulation of the radiation emitted from the power source.

15. The apparatus according claim 1, wherein the mount further comprises a filter configured to prevent transmission to the photosensors of ambient non-visible light.

16. The apparatus according to claim 1, wherein

the driving circuitry is configured to drive the electrodes to apply the currents in stimulation pulses of current, and

the driving circuitry is configured to regulate a number of the stimulation pulses in response to the modulation of the radiation emitted from the power source.

17. The apparatus according to claim 1, wherein

the driving circuitry is configured to drive the electrodes to apply the currents in stimulation pulses of current, and

the driving circuitry is configured to regulate a frequency of the stimulation pulses, in response to the modulation of the radiation emitted from the power source.

18. The apparatus according to claim 1, wherein

the driving circuitry is configured to drive the electrodes to apply the currents in stimulation pulses of current, and

the driving circuitry is configured to regulate a duration of each stimulation pulse, in response to the modulation of the radiation emitted from the power source.

19. The apparatus according to claim 1, wherein

the driving circuitry is configured to drive the electrodes to apply the currents in stimulation pulses of current, and

the driving circuitry is configured to regulate a pulse repetition interval of the stimulation pulses, in response to the modulation of the radiation emitted from the power source.

20. A method for modulating a parameter of an implant configured for implantation in a subject, the method comprising:

providing apparatus, comprising;

an external device, comprising;

a mount, configured to be placed in front of an eye of a subject; and

a power source coupled to the mount and configured to emit radiation that is outside of 380-750 nm; and

an intraocular device configured to be implanted entirely in the subject'"'"'s eye, the intraocular device comprising;

an energy receiver, configured to receive the radiation from the power source and to generate a voltage drop in response thereto;

a plurality of stimulating electrodes;

a plurality of photosensors, each photosensor configured to detect photons and to generate a signal in response thereto; and

driving circuitry, coupled to the energy receiver and to the photosensors, and configured to receive the signals from the photosensors and to utilize the voltage drop to drive the electrodes to apply currents to a retina of the eye in response to the signals from the photosensors,

wherein the external device is configured to modulate the radiation emitted from the power source using an encoding protocol such that pulses of the radiation are encoded by the encoding protocol, and wherein the driving circuitry is configured to regulate a parameter of operation of the driving circuitry in response to the modulation of the radiation emitted from the power source, and wherein the driving circuitry is configured to control a sensitivity of the photosensors, by the regulating of the parameter by the driving circuitry,

emitting the radiation, from the power source to the intraocular device;

receiving an input from the subject, and in response to receiving the input from the subject, modulating the radiation emitted from the power source by using the encoding protocol such that the pulses of the radiation are encoded by the encoding protocol;

regulating the parameter of the driving circuitry of the intraocular device in response to the modulation of the radiation emitted from the power source; and

controlling the sensitivity of the photosensors, by the regulating of the parameter by the driving circuitry.

21. The method according to claim 20, wherein the method further comprises:

using the driving circuitry, driving currents into the electrodes of the intraocular device in stimulation pulses; and

in response to the modulation of the radiation, regulating at least one stimulation parameter selected from the group consisting of;

a number of the stimulation pulses, a frequency of the stimulation pulses, a duration of each stimulation pulse, and a pulse repetition interval of the stimulation pulses.