Apparatus and method for measuring an analyte such as bilirubin, using light

• US 9,279,763 B2
• Filed: 04/27/2011
• Issued: 03/08/2016
• Est. Priority Date: 05/27/2010
• Status: Active Grant

• Current Assignee: Koninklijke Philips N.V.
• Original Assignee: Koninklijke Philips N.V.
• Inventors: Meijer, Eduard Johannes, Kudavelly, Srinivas Rao
• Primary Examiner(s): Lyons, Michael A
• Assistant Examiner(s): Decenzo, Shawn
• Application Number:
  US13/697,120
• Publication Number:
  US 20130057865A1
• Time in Patent Office: 1,777 Days
• US Class Current: 1/1
• CPC Class Codes: A61B 5/1455 using optical sensors, e.g. spectral photometrical oximeters
• CPC Class Codes: A61B 5/443 Evaluating skin constituents, e.g. elastin, melanin, water
• CPC Class Codes: G01N 2021/3144 for oxymetry
• CPC Class Codes: G01N 2021/3148 using three or more wavelengths
• CPC Class Codes: G01N 2021/3177 Use of spatially separated filters in simultaneous way
• CPC Class Codes: G01N 2021/3181 using LEDs
• CPC Class Codes: G01N 21/255 Details, e.g. use of specially adapted sources, lighting or optical systems
• CPC Class Codes: G01N 21/49 within a body or fluid
• CPC Class Codes: G01N 2201/0627 Use of several LED's for spectral resolution
• CPC Class Codes: G01N 2201/0826 Fibre array at source, distributing

Abstract

An analyte measuring device (5) for monitoring, for example, levels of a tissue analyte (e.g., bilirubin), includes a number of narrow band light sources (10), each narrow band light source being structured to emit a spectrum of light covering a number of wavelengths, and a number of detector assemblies (15) configured to receive light reflected from the transcutaneous tissues of a subject. Each of the detector assemblies includes a filter (20) and a photodetector (25), each filter being structured to transmit a main transmission band and one or more transmission sidebands, wherein for each narrow band light source the spectrum thereof includes one or more wavelengths that fall within the transmission band of at least one of the filters, and wherein for each narrow band light source the spectrum thereof does not include any wavelengths that fall within the one or more transmission sidebands of any of the optical filters.

Claims

1. An analyte measuring device, comprising multiple narrow band light sources and multiple detector assemblies, wherein

the multiple detector assemblies include:

a first detector assembly configured to receive light emitted by the multiple narrow band light sources and reflected by a subject, the first detector assembly including a first filter coupled to a first photodetector, wherein the first filter is configured such that light having wavelengths in a main transmission band of the first filter passes through and such that light having wavelengths in one or more transmission sidebands of the first filter passes through;

a second detector assembly configured to receive light emitted by the multiple narrow band light sources and reflected by the subject, the second detector assembly including a second filter coupled to a second photodetector, wherein the second filter is configured such that light having wavelengths in a main transmission band of the second filter passes through and such that light having wavelengths in one or more transmission sidebands of the second filter passes through; and

a third detector assembly configured to receive light emitted by the multiple narrow band light sources and reflected by the subject, the third detector assembly including a third filter coupled to a third photodetector, wherein the third filter is configured such that light having wavelengths in a main transmission band of the third filter passes through and such that light having wavelengths in one or more transmission sidebands of the third filter passes through; and

the multiple narrow band light sources include;

a first narrow band light source being structured to emit a first narrow band spectrum of light covering a first set of wavelengths, wherein the first set of wavelengths includes wavelengths that fall within the main transmission band of one or more of the first filter, the second filter, and the third filter, and wherein the first set of wavelengths does not include any wavelengths that fall within the transmission sidebands of the first filter, the second filter, or the third filter; and

a second narrow band light source being structured to emit a second narrow band spectrum of light covering a second set of wavelengths, wherein the second set of wavelengths includes wavelengths that fall within the main transmission band of one or more of the first filter, the second filter, and the third filter and wherein the second set of wavelengths does not include any wavelengths that fall within the transmission sidebands of the first filter, the second filter, or the third filter;

wherein one or both of the first narrow band light source and the second narrow band light source being structured to emit a narrow band spectrum of light covering wavelengths that fall within the main transmission bands of at least two of the filters.

2. The measuring device according to claim 1, wherein the subject is a human and wherein the analyte is a tissue analyte.

3. The measuring device according to claim 2, wherein the tissue analyte is bilirubin, wherein the multiple detector assemblies are configured to receive light emitted by the multiple narrow band light sources and reflected by transcutaneous tissues of the subject, and wherein the main transmission bands of the filters of the multiple detector assemblies include multiple predetermined wavelengths suitable for determining one or both of a transcutaneous bilirubin (TCB) level and a total serum bilirubin (TSB) level of the subject.

4. The measuring device according to claim 3, further comprising a controller (30) operatively coupled to the multiple narrow band light sources and the multiple detector assemblies, wherein individual photodetectors included in the multiple detector assemblies are configured to generate individual electrical signals based on light received by the individual photodetectors, and wherein the controller is adapted to determine one or both of the TCB level and the TSB level of the subject based on the individual electrical signals received from the individual photodetectors.

5. The measuring device according to claim 3, wherein individual ones of the multiple detector assemblies are shielded from all light except the light reflected by the transcutaneous tissues of the subject.

6. The measuring device according to claim 1, wherein individual ones of the filters are centered at a predetermined wavelength of light and have a predetermined full-width at half maximum.

7. The measuring device according to claim 6, wherein the first narrow band light source includes a cyan LED and wherein the second narrow band light source includes a green LED, and wherein the filters of the multiple detector assemblies include a first filter centered at 484.22 nm with a full-width at half maximum (FWHM) of 5.60714 nm, a second filter centered at 517.61 nm with a FWHM of 6.74956 nm, and a third filter centered at 564.19 nm with a FWHM of 7.35165 nm.

8. The measuring device according to claim 6, wherein individual ones of the filters are an all-dielectric interference filter stack.

9. The measuring device according to claim 1, wherein at least one photodetector is a photodiode.

10. A method of measuring an analyte of a subject, comprising:

directing light from multiple narrow band light sources including a first narrow band light source and a second narrow band light source toward the subject, wherein individual ones of the multiple narrow band light sources emit a narrow-band spectrum of light covering a number of wavelengths, wherein responsive to the directing, emitted light is reflected by the subject;

filtering the reflected light using multiple filters, the filters including a first filter coupled to a first photodetector, a second filter coupled to a second photodetector, and a third filter coupled to a third photodetector, wherein individual ones of the multiple filters have a main transmission band and one or more transmission sidebands, wherein;

for individual ones of the multiple narrow band light sources the emitted narrow-band spectrum includes one or more wavelengths that fall within the main transmission band of at least one of the multiple filters, wherein one or both of the first narrow band light source and the second narrow band light source being structured to emit a narrow band spectrum of light covering wavelengths that fall within the main transmission bands of at least two of the filters, and

for individual ones of the multiple narrow band light sources the emitted narrow-band spectrum does not include any wavelengths that fall within the one or more transmission sidebands of any of the multiple filters, the filtering producing a filtered light associated with individual ones of the multiple filters; and

determining a measurement relating to the analyte based on the filtered light associated with individual ones of the multiple filters.

11. The method according to claim 10, wherein the analyte is a tissue analyte of the subject, wherein the directing comprises directing light from the multiple narrow band light sources toward the skin of the subject, and wherein in response to the directing, the reflected light is reflected by transcutaneous tissues of the subject.

12. The method according to claim 11, wherein the tissue analyte is bilirubin and the method is a method of estimating a bilirubin level of the subject, wherein the determining a measurement relating to the analyte includes determining an estimated bilirubin level based on the filtered light associated with individual ones of the multiple filters.

13. The method according to claim 12, wherein the main transmission bands of the multiple filters include a plurality of predetermined wavelengths required for determining one or both of a transcutaneous bilirubin (TCB) level and a total serum bilirubin (TSB) level of the subject.

14. The method according to claim 12, further comprising generating individual electrical signals based on the filtered light, wherein determining the estimated bilirubin level includes determining one or both of the TCB level and the TSB level of the subject based on the individual electrical signals associated with the filtered light produced by individual ones of the multiple filters.

15. The method according to claim 10, wherein individual ones of the multiple filters are centered at a predetermined wavelength of light and have a predetermined full-width at half maximum.

16. The method according to claim 15, wherein the first narrow band light source emits cyan light and wherein the second light source emits green light, and wherein the multiple filters include a first filter centered at 484.22 nm with a full-width at half maximum (FWHM) of 5.60714 nm, a second filter centered at 517.61 nm with a FWHM of 6.74956 nm, and a third filter centered at 564.19 nm with a FWHM of 7.35165 nm.

17. The method according to claim 15, wherein individual ones of the multiple filters are an all-dielectric interference filter stack.

18. The method according to claim 10, further comprising shielding the multiple filters from all light except the reflected light.