Method and implantable system for blood-glucose concentration monitoring using parallel methodologies
First Claim
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1. An implantable system for monitoring blood-glucose concentration in a patient, comprising:
- an EGM sensing circuit configured to sense one or more cardiac electrical signal and generate EGM data indicative of the one or more cardiac electrical signal;
an EGM analysis unit that is configured to receive the EGM data from the EGM sensing circuit and generate a first metric of blood-glucose concentration using the EGM data;
an oxygen metabolism sensor configured to monitor one or more property of oxygen metabolism and, to generate oxygen metabolism data indicative of the one or more property of oxygen metabolism;
an oxygen metabolism analysis unit configured to receive the oxygen metabolism data from the oxygen metabolism sensor and, to generate a second metric of blood-glucose concentration using the oxygen metabolism data; and
a blood-glucose concentration analysis unit configured to receive the first metric of blood-glucose concentration and the second metric of blood-glucose concentration and, to generate an enhanced metric of blood-glucose concentration.
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Abstract
In an implantable medical device for monitoring glucose concentration in the blood, a blood-glucose concentration analysis is performed using correlations of blood-glucose concentration with measures of metabolic oxygen consumption including oxymetric, and/or temperature. Analysis of electrocardiographic data is used in a parallel method to detect and/or confirm the onset and/or existence and/or extent of hypoglycemia and/or hyperglycemia. Blood-glucose concentration calculation is enhanced by using the combination of the oxygen metabolism analysis and electrocardiographic analysis.
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10 Claims
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1. An implantable system for monitoring blood-glucose concentration in a patient, comprising:
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an EGM sensing circuit configured to sense one or more cardiac electrical signal and generate EGM data indicative of the one or more cardiac electrical signal; an EGM analysis unit that is configured to receive the EGM data from the EGM sensing circuit and generate a first metric of blood-glucose concentration using the EGM data; an oxygen metabolism sensor configured to monitor one or more property of oxygen metabolism and, to generate oxygen metabolism data indicative of the one or more property of oxygen metabolism; an oxygen metabolism analysis unit configured to receive the oxygen metabolism data from the oxygen metabolism sensor and, to generate a second metric of blood-glucose concentration using the oxygen metabolism data; and a blood-glucose concentration analysis unit configured to receive the first metric of blood-glucose concentration and the second metric of blood-glucose concentration and, to generate an enhanced metric of blood-glucose concentration. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9)
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10. An implantable cardiac stimulation device comprising:
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an EGM sensing circuit configured to sense one or more cardiac electrical signal and, to generate EGM data indicative of the one or more cardiac electrical signal; an EGM analysis unit configured to receive the EGM data from the EGM sensing circuit and, to generate a first metric of blood-glucose concentration using the EGM data; an oxygen metabolism input circuit configured to receive oxygen metabolism signals indicative of one or more property of oxygen metabolism and, to generate oxygen metabolism data using the oxygen metabolism signals; an oxygen metabolism analysis unit configured to receive the oxygen metabolism data from the oxygen metabolism input circuit, and to generate a second metric of blood-glucose concentration using the oxygen metabolism data; a blood-glucose concentration analysis unit configured to receive the first metric of blood-glucose concentration and the second metric of blood-glucose concentration, and to generate an enhanced metric of blood-glucose concentration; and an effector that is configured to deliver at least one of a therapy, a diagnosis and a warning in response to the enhanced metric of blood-glucose concentration.
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Specification