More potent and less toxic formulations of epinephrine and methods of medical use

CAFC
  • US 9,283,197 B1
  • Filed: 08/15/2014
  • Issued: 03/15/2016
  • Est. Priority Date: 08/15/2014
  • Status: Active Grant
First Claim
Patent Images

1. A liquid pharmaceutical formulation of preservative-free and sulfite-free, 1 mg per mL l-epinephrine sterile solution for uses including injection;

  • said liquid pharmaceutical formulation having a pH between 2.8 and 3.3;

    said liquid pharmaceutical formulation compounded in an aqueous solution as 1.0 to 1.06 mg/mL l-epinephrine, and further including a tonicity agent;

    said liquid pharmaceutical formulation having no more than 6.5% total impurities at release, including no more than 6% d-epinephrine and no more than 0.5% adrenalone, and no more than 12.5% total impurities over a shelf-life of at least 12 months, including no more than 12% d-epinephrine and no more than 0.5% adrenalone;

    said liquid pharmaceutical formulation stored in a container with an inert gas prior to use.

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