Coordination of ventricular pacing in a leadless pacing system

• US 9,289,612 B1
• Filed: 12/11/2014
• Issued: 03/22/2016
• Est. Priority Date: 12/11/2014
• Status: Active Grant

• Current Assignee: Medtronic Incorporated (Medtronic Plc)
• Original Assignee: Medtronic Incorporated (Medtronic Plc)
• Inventors: Sambelashvili, Aleksandre T, Sheldon, Todd J, Cho, Yong K
• Primary Examiner(s): Patton, Amanda
• Assistant Examiner(s): Edwards, Philip
• Application Number:
  US14/567,609
• Time in Patent Office: 467 Days
• Field of Search: 607/32, 607/59, 607/60
• US Class Current: 1/1
• CPC Class Codes: A61N 1/36578 controlled by mechanical motion of the heart wall, e.g. measured by an accelerometer or microphone
• CPC Class Codes: A61N 1/368 comprising more than one electrode co-operating with different heart regions A61N1/3622, A61N1/3627 take precedence
• CPC Class Codes: A61N 1/3682 with a variable atrioventricular delay
• CPC Class Codes: A61N 1/3756 Casings with electrodes thereon, e.g. leadless stimulators

Abstract

An implantable medical system is configured to coordinate ventricular pacing with intrinsic depolarizations of another chamber. The implantable medical system includes a leadless pacing device implanted on or within the ventricle. Another implantable medical device is configured to sense an intrinsic depolarization the other chamber of the heart of the patient, and in response to the intrinsic depolarization of the other chamber, deliver an electrical pulse. The leadless pacing device is configured to detect the electrical pulse delivered by the other implantable medical device and, in response to detecting the electrical pulse delivered by the other implantable medical device, deliver a pacing pulse to the ventricle via at least a first electrode in coordination with the intrinsic depolarization of the other chamber.

Claims

1. An implantable medical system configured to coordinate ventricular pacing with intrinsic depolarizations of another chamber of a heart of a patient, the system comprising:

a leadless pacing system comprising;

a leadless pacing device comprising;

a stimulation module configured to generate pacing pulses;

a sensing module;

a processing module;

a housing configured to be implanted on or within a ventricle of the heart, wherein the housing encloses the stimulation module, the sensing module, and the processing module; and

a first electrode electrically coupled to the sensing module and the stimulation module; and

a sensing extension extending from the housing and comprising;

a body extending from the housing; and

a second electrode carried by the body and electrically connected to the sensing module and the stimulation module,

wherein the sensing module is configured to sense electrical activity of the ventricle via the first and second electrodes, and the stimulation module is configured to deliver pacing pulses to the ventricle via at least the first electrode; and

another implantable medical device configured to;

sense an intrinsic depolarization of the other chamber of the heart of the patient, and

in response to the intrinsic depolarization of the other chamber, deliver an electrical pulse,

wherein the sensing module of the leadless pacing device is configured to detect the electrical pulse delivered by the other implantable medical device via the first electrode and the second electrode,

wherein, in response to the sensing module of the leadless pacing device detecting the electrical pulse delivered by the other implantable medical device, the processing module of the leadless pacing device is configured to control the stimulation module of the leadless pacing device to generate a pacing pulse for delivery to the ventricle via at least the first electrode in coordination with the intrinsic depolarization of the other chamber.

2. The implantable medical system of claim 1, wherein the processing module is configured to control the stimulation module of the leadless pacing device to generate the pacing pulse for delivery to the ventricle a delay interval after the sensing module of the leadless pacing device detects the electrical pulse delivered by the other implantable medical device.

3. The implantable medical system of claim 2, wherein the other chamber is an atrium, and the delay interval is an atrio-ventricular (AV) delay interval.

4. The implantable medical system of claim 3, wherein the leadless pacing device comprises a first leadless pacing device, the stimulation module comprises a first stimulation module, the sensing module comprises a first sensing module, the processing module comprises a first processing module, and the housing comprises a first housing, and wherein the other implantable medical device comprises a second leadless pacing device comprising:

a second stimulation module configured to generate pacing pulses;

a second sensing module;

a second processing module;

a second housing configured to be implanted within the atrium, wherein the second housing encloses the second stimulation module, the second sensing module, and the second processing module, and wherein the second housing comprises a third electrode and a fourth electrode, and

wherein the second sensing module is configured to detect the intrinsic depolarization of the atrium via the third electrode and the fourth electrode,

wherein, in response to the second sensing module detecting the intrinsic depolarization of the atrium, the second processing module is configured to control the second stimulation module to deliver the electrical pulse via the third electrode and the fourth electrode, and

wherein the electrical pulse comprises a pacing pulse delivered during a refractory period of the atrium.

5. The implantable medical system of claim 2, wherein the ventricle is a first ventricle, the other chamber is a second ventricle, and the interval comprises a ventricular-ventricular (VV) delay interval.

6. The implantable medical system of claim 1, wherein the other implantable medical device is configured to deliver the electrical pulse an interval after sensing the intrinsic depolarization of other chamber of the heart.

7. The implantable medical system of claim 1, wherein the processing module of the leadless pacing device is configured to:

detect activation of the ventricle, and

configure the sensing module to detect the electrical pulse during a pulse detection window that begins a predetermined pulse detection delay interval after activation of the ventricle.

8. The implantable medical system of claim 7, wherein the processing module is configured to adjust a sensitivity of the sensing module for detection of the electrical pulse during the pulse detection window.

9. The implantable medical system of claim 1, wherein the other implantable medical device is configured to deliver the electrical pulse having a predetermined duration to indicate the depolarization of the other chamber to the leadless pacing device, and the processing module of the leadless pacing device is configured to control the stimulation module of the leadless pacing device to generate the pacing pulse for delivery to the ventricle in response to detecting the electrical pulse having the predetermined duration.

10. The implantable medical system of claim 1, wherein the body of the sensing extension is self-supporting and, when the leadless pacemaker device is implanted proximate an apex of a right ventricle of the heart, configured to extend towards a right atrium of the heart while remaining in the right ventricle of the heart.

11. The system of claim 10, wherein the self-supporting body is devoid of any fixation elements.

12. An implantable medical system configured to provide atrio-synchronous ventricular pacing, the system comprising:

a leadless pacing system comprising;

a first leadless pacing device comprising;

a first stimulation module configured to generate pacing pulses;

a first sensing module;

a first processing module;

a first housing configured to be implanted within a right ventricle of a heart of a patient, wherein the first housing encloses the first stimulation module, the first sensing module, and the first processing module; and

a first electrode electrically coupled to the first sensing module and the first stimulation module; and

a sensing extension extending from the first housing and comprising;

a body extending from the first housing; and

a second electrode carried by the body and electrically connected to the first sensing module and the first stimulation module,

wherein the first sensing module is configured to sense electrical activity of the right ventricle via the first and second electrodes, and the first stimulation module is configured to deliver pacing pulses to the right ventricle via at least the first electrode; and

a second leadless pacing device comprising;

a second stimulation module configured to generate pacing pulses;

a second sensing module;

a second processing module;

a second housing configured to be implanted within a right atrium of the heart of the patient, wherein the second housing encloses the second stimulation module, the second sensing module, and the second processing module, and wherein the second housing comprises a third electrode and a fourth electrode, and

wherein the second sensing module of the second leadless pacing device is configured to detect an intrinsic depolarization of the atrium via the third electrode and the fourth electrode,

wherein the second stimulation module of the second leadless pacing device is configured to generate pacing pulses, and

wherein, in response to the second sensing module detecting the intrinsic depolarization of the atrium, the second processing module of the second leadless pacing device is configured to control the second stimulation module of the second leadless pacing device to deliver a pacing pulse via the third electrode and the fourth electrode during a refractory period of the right atrium following the intrinsic depolarization of the right atrium,

wherein the first sensing module of the first leadless pacing device is configured to detect, via the first electrode and the second electrode, the pacing pulse delivered by the second leadless pacing device, and

wherein, in response to the first sensing module of the first leadless pacing device detecting the pacing pulse delivered by the second leadless pacing device, the first processing module of the first leadless pacing device is configured to control the first stimulation module of the first leadless pacing device to generate a pacing pulse for delivery to the right ventricle via at least the first electrode an atrio-ventricular (AV) delay interval after the first sensing module detected the pacing pulse delivered by the second leadless pacing device.

13. A method for coordinating ventricular pacing by a leadless pacing system with intrinsic depolarizations of another chamber of a heart of a patient, wherein the leadless pacing system comprises:

a leadless pacing device comprising;

a stimulation module configured to generate pacing pulses;

a sensing module;

a processing module;

a housing configured to be implanted on or within a ventricle of the heart, wherein the housing encloses the stimulation module, the sensing module, and the processing module; and

a first electrode electrically coupled to the sensing module and the stimulation module; and

a sensing extension extending from the housing and comprising;

a body extending from the housing; and

a second electrode carried by the body and electrically connected to the sensing module and the stimulation module,

wherein the sensing module is configured to sense electrical activity of the ventricle via the first and second electrodes, and the stimulation module is configured to deliver pacing pulses to the ventricle via at least the first electrode,

wherein the method comprises;

sensing, by another implantable medical device, an intrinsic depolarization of the other chamber of the heart of the patient;

in response to sensing the intrinsic depolarization of the other chamber, delivering, by the other implantable medical device, an electrical pulse;

detecting, by the sensing module of the leadless pacing device, the electrical pulse delivered by the other implantable medical device via the first electrode and the second electrode; and

in response detecting the electrical pulse delivered by the other implantable medical device, delivering, by the stimulation module of the leadless pacing device, a pacing pulse to the ventricle via at least the first electrode in coordination with the intrinsic depolarization of the other chamber.

14. The method of claim 13, wherein generating the pacing pulse for delivery to the ventricle comprises generating the pacing pulse for delivery to the ventricle a delay interval after detecting the electrical pulse delivered by the other implantable medical device.

15. The method of claim 14, wherein the other chamber is an atrium, and the delay interval is an atrio-ventricular (AV) delay interval.

16. The method of claim 15, wherein the leadless pacing device comprises a first leadless pacing device, the stimulation module comprises a first stimulation module, the sensing module comprises a first sensing module, the processing module comprises a first processing module, and the housing comprises a first housing, and wherein the other implantable medical device comprises a second leadless pacing device comprising:

a second stimulation module configured to generate pacing pulses;

a second sensing module;

a second processing module;

a second housing configured to be implanted within the atrium, wherein the second housing encloses the second stimulation module, the second sensing module, and the second processing module, and wherein the second housing comprises a third electrode and a fourth electrode, and

wherein detecting the intrinsic depolarization of the other chamber comprises detecting, by the second sensing module of the second leadless pacing device, the intrinsic depolarization of the atrium via the third electrode and the fourth electrode, and

wherein delivering the electrical pulse comprises delivering, in response to detecting the intrinsic depolarization of the atrium, by the second stimulation module of the second leadless pacing device, a pacing via the third electrode and the fourth electrode during a refractory period of the atrium.

17. The method of claim 14, wherein the ventricle is a first ventricle, the other chamber is a second ventricle, and the interval comprises a ventricular-ventricular (VV) delay interval.

18. The method of claim 13, wherein delivering the electrical pulse comprises delivering, by the other implantable medical device, the electrical pulse an interval after sensing the intrinsic depolarization of other chamber of the heart.

19. The method of claim 13, further comprising:

detecting, by the processing module of the leadless pacing device, activation of the ventricle; and

configuring, by the processing module of the leadless pacing device, the sensing module to detect the electrical pulse during a pulse detection window that begins a predetermined pulse detection delay interval after activation of the ventricle.

20. The method of claim 19, wherein configuring the sensing module to detect the electrical pulse during the pulse detection window comprises adjusting a sensitivity of the sensing module for detection of the electrical pulse during the pulse detection window.

21. The method of claim 13, wherein delivering the electrical pulse comprises delivering, by the other implantable medical device, the electrical pulse with a predetermined duration to indicate the depolarization of the other chamber to the leadless pacing device, and wherein delivering the pacing pulse comprises delivering, by the stimulation module of the leadless pacing device, the pacing pulse to the ventricle in response to detecting the electrical pulse having the predetermined duration.