Fiber optic analyte sensor with integrated in situ total pressure correction
First Claim
1. An in situ analyte-sensing fiber optic instrument, comprising (i) a tube having a distal end and an inner surface defining a lumen, (ii) an analyte-partial-pressure-sensitive photoluminescent probe located proximate a distal end of the lumen and in fluid communication with a fluid occupying a volume external to the distal end of the tube through an opening in the tube, and (iii) at least one fiber optic filament having an outer surface, extending axially along the length of the lumen and in optical communication with the analyte-partial-pressure-sensitive photoluminescent probe, the instrument further comprising:
- (a) a void volume channel extending axially along the length of the lumen between the inner surface of the tube and the outer surface of the at least one fiber optic filament, and(b) a pressure sensor in pressure communication via the void volume channel in the lumen of the tube with the fluid from the volume communicating with the analyte-partial-pressure-sensitive photoluminescent probe via the opening in the tube.
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Accused Products
Abstract
A fiber optic analyte sensing needle employing an analyte-partial-pressure-sensitive photoluminescent probe, characterized by (i) a void volume channel extending axially along the length of the lumen between the inner surface of the tube and the outer surface of the fiber optic filament, and (ii) a total pressure sensor in pressure communication with the distal tip of the needle via the void volume channel, whereby total pressure of a volume sampled by the sensing needle can be routinely measured and used in pressure compensation of analyte-concentration values calculated from the analyte-partial-pressure readings taken from the analyte-partial-pressure-sensitive photoluminescent probe.
29 Citations
19 Claims
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1. An in situ analyte-sensing fiber optic instrument, comprising (i) a tube having a distal end and an inner surface defining a lumen, (ii) an analyte-partial-pressure-sensitive photoluminescent probe located proximate a distal end of the lumen and in fluid communication with a fluid occupying a volume external to the distal end of the tube through an opening in the tube, and (iii) at least one fiber optic filament having an outer surface, extending axially along the length of the lumen and in optical communication with the analyte-partial-pressure-sensitive photoluminescent probe, the instrument further comprising:
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(a) a void volume channel extending axially along the length of the lumen between the inner surface of the tube and the outer surface of the at least one fiber optic filament, and (b) a pressure sensor in pressure communication via the void volume channel in the lumen of the tube with the fluid from the volume communicating with the analyte-partial-pressure-sensitive photoluminescent probe via the opening in the tube. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10)
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11. A handheld instrument for impromptu in situ concomitant sensing of oxygen partial pressure and total pressure of a hermetically sealed volume, comprising an integrated combination of at least:
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(a) a hollow shank having a proximal end, a distal end and an inner surface defining a lumen in fluid communication with a volume external to the distal end, (b) an oxygen-partial-pressure-sensitive photoluminescent probe within the lumen proximate the distal end of the shank and in fluid communication with a fluid occupying a volume external to the distal end of the shank through an opening in the shank, (c) an electronics package proximate the proximal end of the shank, including at least; (i) a source of excitation radiant energy, (ii) a photoluminescence detector, and (iii) a pressure sensor, and (d) at least one fiber optic filament having an outer surface and extending axially along the length of the lumen operable for (i) transmitting excitation radiant energy from the source of excitation radiant energy to the oxygen-partial-pressure-sensitive photoluminescent probe, and (ii) transmitting radiant energy emitted by the oxygen-partial-pressure-sensitive photoluminescent probe to the photoluminescence detector, and configured relative to the lumen to form a void volume channel extending axially along the length of the lumen between the inner surface of the shank and the outer surface of the at least one fiber optic filament, wherein (e) the pressure sensor is in pressure communication via the void volume channel in the lumen of the shank with the fluid from the volume communicating with the oxygen-partial-pressure-sensitive photoluminescent probe via the opening in the shank. - View Dependent Claims (12, 13, 14, 15, 16, 17, 18, 19)
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Specification