Particle-containing membrane and particulate electrode for analyte sensors

• US 9,339,222 B2
• Filed: 05/31/2013
• Issued: 05/17/2016
• Est. Priority Date: 09/19/2008
• Status: Active Grant

• Current Assignee: DexCom Incorporated
• Original Assignee: DexCom Incorporated
• Inventors: Simpson, Peter C., Boock, Robert J., Wightlin, Matthew D., Shults, Mark C.
• Primary Examiner(s): JANG, CHRISTIAN YONGKYUN
• Application Number:
  US13/907,507
• Publication Number:
  US 20130261417A1
• Time in Patent Office: 1,082 Days
• US Class Current: 1/1
• CPC Class Codes: A61B 2562/028 Microscale sensors, e.g. electromechanical sensors [MEMS]
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/14546 for measuring analytes not otherwise provided for, e.g. ions, cytochromes
• CPC Class Codes: A61B 5/1473 invasive, e.g. introduced into the body by a catheter A61B5/1482 takes precedence
• CPC Class Codes: A61B 5/14865 invasive, e.g. introduced into the body by a catheter or needle or using implanted sensors
• CPC Class Codes: A61B 5/6848 Needles

Abstract

Systems and methods of use involving sensors having a particle-containing domain are provided for continuous analyte measurement in a host. In some embodiments, a continuous analyte measurement system is configured to be wholly, transcutaneously, intravascularly or extracorporeally implanted.

Claims

1. A system for continuous in vivo measurement of an analyte in a host, the system comprising:

a continuous analyte sensor configured for implantation in a host and configured to generate a signal indicative of an analyte concentration; and

a layer disposed over at least a portion of the sensor, wherein the layer comprises a particle-containing domain comprising a metal, wherein the particle-containing domain is configured to react with at least one interfering species.

2. The system of claim 1, wherein the particle-containing domain is more distal to the sensor than other domains of the layer.

3. The system of claim 1, wherein the particle-containing domain comprises at least one material selected from the group consisting of platinum, platinum-iridium, iridium, palladium, graphite, gold, silver, silver chloride, carbon, and conductive polymers.

4. The system of claim 1, wherein the metal comprises sputtered metal.

5. The system of claim 4, wherein the sputtered metal is platinum.

6. The system of claim 1, wherein the particle-containing domain comprises a conductive particles concentration that is sufficient for the particle-containing domain to function as a conductive film.

7. The system of claim 1, wherein the particle-containing domain is configured to reduce flux therethrough of hydrogen peroxide.

8. The system of claim 1, wherein the particle-containing domain is non-powered.

9. The system of claim 1, wherein the particle-containing domain is powered.

10. The system of claim 9, wherein the sensor electronics are configured to apply a potential to the particle-containing domain.

11. The system of claim 1, wherein the layer comprises an analyte-permeable polymer.

12. The system of claim 11, wherein the analyte-permeable polymer comprises a hydrophilic polymer.

13. The system of claim 11, wherein the analyte-permeable polymer comprises at least one of polyurethane or silicone.

14. The system of claim 1, wherein the interfering species interferes with measurement of the analyte concentration to produce a signal that does not accurately represent the analyte concentration.

15. The system of claim 1, wherein the interfering species is a reactive metabolic species.

16. The system of claim 1, wherein the interfering species is a reactive oxygen species.

17. The system of claim 1, wherein the interfering species is a reactive nitrogen species.

18. The system of claim 1, wherein the interfering species is H₂O₂.