Cognitive function assessment in a patient

• US 9,339,227 B2
• Filed: 06/17/2011
• Issued: 05/17/2016
• Est. Priority Date: 06/22/2010
• Status: Active Grant

• Current Assignee: National Research Council Canada
• Original Assignee: National Research Council Canada
• Inventors: D'arcy, Ryan, Weaver, Donald F., Hajra, Sujoy Ghosh, Liu, Careesa, Sculthorpe-Petley, Lauren
• Primary Examiner(s): Le, Long V
• Assistant Examiner(s): IMPINK, BRADLEY GERALD
• Application Number:
  US13/701,252
• Publication Number:
  US 20130245422A1
• Time in Patent Office: 1,796 Days
• Field of Search: None
• US Class Current: 1/1
• CPC Class Codes: A61B 5/165 Evaluating the state of mind, e.g. depression, anxiety
• CPC Class Codes: A61B 5/246 using evoked responses
• CPC Class Codes: A61B 5/316 Modalities, i.e. specific diagnostic methods
• CPC Class Codes: A61B 5/377 using evoked responses
• CPC Class Codes: A61B 5/38 Acoustic or auditory stimuli
• CPC Class Codes: A61B 5/4842 Monitoring progression or stage of a disease
• CPC Class Codes: A61B 5/7246 using correlation, e.g. template matching or determination of similarity

Abstract

A method for analysis of the extent of conscious awareness and likelihood of recovery of a patient includes the steps of applying to the patient a sensory stimulus sequence which is typically auditory; carrying out an EEG to generate waveform signals to record changes in the electromagnetic fields generated by the patient'"'"'s neural activity; using software provided in a processor to process the waveform signals in order to locate waveform peaks, identify the event-related potential (ERP) components obtained in the waveform and to obtain quantitative measures of those components; and using the software to generate and communicate scores indicative of the extent of conscious awareness and likelihood of recovery of the patient.

Claims

1. A method for analysis of the extent of conscious awareness and/or likelihood of recovery of a patient comprising:

applying to the patient a sensory stimulus sequence generated by a stimulator;

while applying the stimulus sequence, carrying out an EEG or MEG on the patient to record waveform signals from an array of sensors on, in, or near the head of the patient;

wherein the stimulus sequence comprises a compressed stimulus sequence that elicits at least five indicators across a spectrum of brain functions comprising sensory processing, perceptual processing, attention/alerting mechanisms, memory retrieval, and language;

using software provided in a processor to process the waveform signals in order to locate waveform peaks, identify the evoked responses contained in the waveform and obtain quantitative measures of these evoked responses;

wherein the software uses an automated peak localization method that performs a mathematical decomposition of an averaged waveform to identify all peaks in the waveform signals; and

wherein the software then applies identification criteria to choose a candidate peak of interest;

and using the software to generate and communicate scores based on the quantitative measures that are indicative of the extent of conscious awareness and/or likelihood of recovery of the patient.

2. The method according to claim 1 wherein the compressed stimulus sequence takes less than 5 minutes.

3. The method according to claim 1 wherein the software generates scores comprising a diagnostic score and wherein points in the diagnostic score are allotted based on said evoked responses related to said plurality of brain functions.

4. The method according to claim 1 wherein the software generates scores comprising a diagnostic score and wherein points in the diagnostic score are allotted based on the statistical assessment of differences between quantitative measures of the patient'"'"'s evoked responses and normative values from a database.

5. The method according to claim 1 wherein the software generates scores comprising a prognostic score and wherein points in the prognostic score are allotted based on the statistical relationships between averaged waveform features and historical outcomes of patients diagnosed with the same condition.

6. The method according to claim 1, wherein the peak localization method identifies all peaks by determining the zero crossings of the averaged waveform'"'"'s first and second derivatives, yielding peak and inflection points of the waveform'"'"'s curvature.

7. The method according to claim 1, wherein the peak localization method employs an amplitude thresholding method whereby small peaks are rejected from further analysis.

8. The method according to claim 1, wherein the identification criteria are applied that describe generic ERP/ERF component characteristics based on several basic features, such as experimental condition, latency, and polarity.

9. The method according to claim 1, wherein the peak localization method takes into account the peak'"'"'s shape and curvature, its relationship to peaks in other averaged waveforms for different experimental conditions, and the shape and curvature of the averaged waveform between this peak and its neighboring peak.

10. The method according to claim 1, wherein the software uses an adaptive pattern recognition process to perform a series of automated and iterative adjustments to the previously described identification criteria to accommodate, where possible, the differences between individuals.

11. The method according to claim 1, wherein the pattern recognition process to examine relationships with peaks in waveforms for different experimental conditions, such as relative amplitudes and crossover points between the waveforms.